Emerging in vitro platforms and omics technologies for studying the endometrium and early embryo-maternal interface in humans.
Human reproductive success relies on the intricate interplay between the developing embryo and the maternal endometrium. These highly-coordinated interactions facilitate implantation, setting in motion a series of developmental programs to establish a sustained fetal-maternal interface. Understandin...
| Published in: | Placenta Vol. 125; pp. 36 - 47 |
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| Main Authors: | , |
| Format: | review Journal Article |
| Published: |
Elsevier B.V.
Jul2022
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=157441817&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 157441817 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01434004 NZZ jtl: Placenta issn: 01434004 maglogo: N pubinfo: dt: Jul2022 vid: 125 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 157441817 157441817 NLM35078656 157441817 10.1016/j.placenta.2022.01.006 NLM35078656 157441817 ppf: 36 ppct: 11 formats: tig: atl: Emerging in vitro platforms and omics technologies for studying the endometrium and early embryo-maternal interface in humans. aug: au: Popovic, Mina Chuva de Sousa Lopes, Susana M. affil: Basic Research Laboratory - Eugin Group, Barcelona, Spain sug: subj: Abortion, Spontaneous Endometrium Embryo Tissue Culture Techniques Pregnancy Female Fetal Development Physiology Female ab: Human reproductive success relies on the intricate interplay between the developing embryo and the maternal endometrium. These highly-coordinated interactions facilitate implantation, setting in motion a series of developmental programs to establish a sustained fetal-maternal interface. Understanding endometrial function and the early human embryo-maternal dialogue is thus an important prerequisite for refining clinical approaches to alleviate implantation failure, early pregnancy loss and other obstetric complications. Yet, many mediators of implantation remain elusive. Driven by endocrine factors, interactions at the embryo-maternal interface are tightly regulated and highly complex. Coupled to the inaccessibility of the in vivo environment and scarcity of research material, studying human implantation remains exceptionally challenging. Nevertheless, the field continues to gain momentum. Cutting-edge omics technologies and high-resolution imaging have revealed important structural and functional insights into endometrial biology, while emerging bioengineering tools are enhancing our ability to model the synergies and individual features of the embryo-maternal environment. Novel in vitro platforms using human cells and embryos are considerably more accessible and easier to manipulate compared to in vivo approaches, enhancing our ability to capture specific stages of implantation. This review aims to showcase current and emerging technologies used to study human endometrial biology and the early embryo-maternal interface, including single cell omics approaches, bioengineered endometrial models and embryo-endometrium co-culture platforms. We highlight the value of these approaches and provide our perspective on the current challenges faced by the field. Recognizing the physiological scope of these emerging technologies will be key for utilizing their full potential and driving future innovation. pubtype: Academic Journal doctype: review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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