Set‐up of a population‐based model to verify alcohol abstinence via monitoring of the direct alcohol marker phosphatidylethanol 16:0/18:1.
Background and aims: Phosphatidylethanol 16:0/18:1 (PEth) is a biomarker for alcohol intake. It has a half‐life of 7.9 days. Chronic alcohol consumption causes high PEth values. It can take weeks before PEth values fall below the decision limit for 'alcohol abstinence'. Our aim was to validate wheth...
| Publicado en: | Addiction Vol. 117; no. 7; pp. 2108 - 2119 |
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| Autores principales: | , , , |
| Formato: | algorithm research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Jul2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=157443565&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 157443565 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09652140 AIO jtl: Addiction issn: 09652140 maglogo: Y pubinfo: dt: Jul2022 vid: 117 iid: 7 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 157443565 155200256 157443565 157443565 10.1111/add.15811 157443565 ppf: 2108 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Set‐up of a population‐based model to verify alcohol abstinence via monitoring of the direct alcohol marker phosphatidylethanol 16:0/18:1. aug: au: Van Uytfanghe, Katleen Heughebaert, Liesl Abatih, Emmanuel Stove, Christophe P. affil: Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium sug: subj: Alcohol Abstinence Belgium Phospholipids Blood Ethanol Blood Monitoring, Physiologic Biological Markers Blood Human Nonexperimental Studies Belgium Chromatography, Liquid Mass Spectrometry Algorithms Sensitivity and Specificity Decision Trees Descriptive Statistics Adolescence Adult Middle Age Aged Aged, 80 and Over Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over ab: Background and aims: Phosphatidylethanol 16:0/18:1 (PEth) is a biomarker for alcohol intake. It has a half‐life of 7.9 days. Chronic alcohol consumption causes high PEth values. It can take weeks before PEth values fall below the decision limit for 'alcohol abstinence'. Our aim was to validate whether alcohol abstinence can be determined based on two consecutive PEth results above the decision limit. Design Observational study. Setting: Belgium, February 2019. The study was linked to a social initiative in Belgium, 'Tournée Minérale'. Participants: Adults (aged > 18 years, n = 796) with varying drinking habits who self‐reportedly refrained from alcohol consumption during the study. Measurements A validated liquid chromatography–tandem mass spectrometry method was used to quantify PEth in participants' dried blood samples, collected at three time‐points via remote fingerprick‐based self‐sampling. Findings A population‐based algorithm to evaluate abstinence based on 95% prediction limits was developed by fitting a linear mixed‐effect model to discern patterns in PEth elimination over time. It took intra‐ and inter‐individual variability into consideration. The algorithm was included in a two‐step decision tree, assessing whether (i) PEth values fell within the prediction interval and (ii) the slope between two PEth values was consistent with no alcohol consumption. Data for 74 participants reporting no alcohol intake during the study were used for validation. With a detection limit of 'four units spread over 14 days', the sensitivity and specificity of the decision tree was 89%. Conclusions: Claims of alcohol abstinence can be verified using a two‐step decision tree for phosphatidylethanol 16:0/18:1 values, even when those values are above the limit for 'alcohol abstinence'. pubtype: Academic Journal doctype: algorithm research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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