Association of smoking, lung function and COPD in COVID‐19 risk: a two‐step Mendelian randomization study.
Background and Aims: Smoking increases the risk of severe COVID‐19, but whether lung function or chronic obstructive pulmonary disease (COPD) mediate the underlying associations is unclear. We conducted the largest Mendelian randomization study to date, to our knowledge, to address these questions....
| Publicado en: | Addiction Vol. 117; no. 7; pp. 2027 - 2037 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Wiley-Blackwell
Jul2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=157443576&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 157443576 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09652140 AIO jtl: Addiction issn: 09652140 maglogo: Y pubinfo: dt: Jul2022 vid: 117 iid: 7 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 157443576 155592407 157443576 157443576 10.1111/add.15852 157443576 ppf: 2027 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Association of smoking, lung function and COPD in COVID‐19 risk: a two‐step Mendelian randomization study. aug: au: Au Yeung, Shiu Lun Li, Albert Martin He, Baoting Kwok, Kin On Schooling, C Mary affil: School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China sug: subj: Smoking Complications Lung Physiology Pulmonary Disease, Chronic Obstructive Complications COVID-19 Risk Factors Risk Assessment Human Randomized Controlled Trials Genome Wide Association Study Comparative Studies Odds Ratio Confidence Intervals ab: Background and Aims: Smoking increases the risk of severe COVID‐19, but whether lung function or chronic obstructive pulmonary disease (COPD) mediate the underlying associations is unclear. We conducted the largest Mendelian randomization study to date, to our knowledge, to address these questions. Design Mendelian randomization study using summary statistics from genome‐wide association studies (GWAS), FinnGen and UK Biobank. The main analysis was the inverse variance weighted method, and we included a range of sensitivity analyses to assess the robustness of the findings. Setting: GWAS which included international consortia, FinnGen and UK Biobank. Participants: The sample size ranged from 193 638 to 2 586 691. Measurements Genetic determinants of life‐time smoking index, lung function [e.g. forced expiratory volume in 1 sec (FEV1)], chronic obstructive pulmonary disease (COPD) and different severities of COID‐19. Results: Smoking increased the risk of COVID‐19 compared with population controls for overall COVID‐19 [odds ratio (OR) = 1.19 per standard deviation (SD) of life‐time smoking index, 95% confidence interval (CI) = 1.11–1.27], hospitalized COVID‐19 (OR = 1.67, 95% CI = 1.42–1.97) or severe COVID‐19 (OR = 1.48, 95% CI = 1.10–1.98), with directionally consistent effects from sensitivity analyses. Lung function and COPD liability did not appear to mediate these associations. Conclusion: There is genetic evidence that smoking probably increases the risk of severe COVID‐19 and possibly also milder forms of COVID‐19. Decreased lung function and increased risk of chronic obstructive pulmonary disease do not seem to mediate the effect of smoking on COVID‐19 risk. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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