Dietary Intake is Associated with miR-31 and miR-375 Expression in Patients with Head and Neck Squamous Cell Carcinoma.
MicroRNAs (miRNAs) are important epigenetic regulators in head and neck squamous cell carcinoma (HNSCC), with miR-31 being considered an oncomir and miR-375, a tumor suppressor miR, which are up- and down-regulated in HNSCC, respectively. Nutrients are known to influence miRNA expression; however, t...
| Publicado en: | Nutrition & Cancer Vol. 74; no. 6; pp. 2049 - 2059 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=157520010&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 157520010 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2022 vid: 74 iid: 6 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 157520010 152988655 157520010 157520010 10.1080/01635581.2021.1990972 157520010 ppf: 2049 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Dietary Intake is Associated with miR-31 and miR-375 Expression in Patients with Head and Neck Squamous Cell Carcinoma. aug: au: Ferreira, Tathiany Jéssica de Araújo, Caroline Castro Lima, Ana Carolina da Silva Matida, Larissa Morinaga Griebeler, Ana Flávia Mendes Coelho, Alexandre Siqueira Guedes Gontijo, Antônio Paulo Machado Cominetti, Cristiane Vêncio, Eneida Franco Horst, Maria Aderuza affil: Nutritional Genomics Research Group, School of Nutrition, Federal University of Goias, Goiania, Brazil sug: subj: MicroRNA Metabolism Food Intake Squamous Cell Carcinoma of Head and Neck Diet Therapy Cancer Patients Gene Expression Human Iron Ascorbic Acid Blood Glucose Cholesterol Folic Acid Zinc Selenium Vitamin D Phosphorus Vitamin B12 Epigenomics Descriptive Statistics Dietary Supplementation ab: MicroRNAs (miRNAs) are important epigenetic regulators in head and neck squamous cell carcinoma (HNSCC), with miR-31 being considered an oncomir and miR-375, a tumor suppressor miR, which are up- and down-regulated in HNSCC, respectively. Nutrients are known to influence miRNA expression; however, this association is poorly explored in HNSCC. This work aimed to identify associations between dietary intake and the expression of miR-31 and miR-375 in patients newly diagnosed with HNSCC. The expression of miR-31 was positively associated with the consumption of iron (β = 16.65) and vitamin C (β = 0.37), and inversely associated with total sugar (β = −0.88), cholesterol (β= −0.23), vitamin B9 (β= −0.37) and zinc (β = −5.66) intake. The expression of miR-375 was positively associated with the consumption of selenium (β = 1.52), vitamin C (β = 0.17) and vitamin D (β = 13.01), and inversely associated with the consumption of added sugar (β = −0.49), phosphorus (β= −0.27) and vitamin B12 (β = −10.80). Our findings showed important associations between dietary intake and miR-31 and miR-375 expression in HNSCC, offering possible directions for further studies investigating how nutrients interfere with carcinogenesis. Supplemental data for this article is available online at https://doi.org/10.1080/01635581.2021.1990972. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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