Sex differences in neurobehavioral consequences of methamphetamine exposure in adult mice.
Rationale: Recreational and medical use of stimulants is increasing, and their use may increase susceptibility to aging and promote neurobehavioral impairments. The long-term consequences of these psychostimulants and how they interact with age have not been fully studied. Objectives: Our study inve...
| Publicado en: | Psychopharmacology Vol. 239; no. 7; pp. 2331 - 2350 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jul2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=157528542&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 157528542 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Jul2022 vid: 239 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 157528542 155974726 10.1007/s00213-022-06122-8 157528542 ppf: 2331 ppct: 19 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Sex differences in neurobehavioral consequences of methamphetamine exposure in adult mice. aug: au: Davis, Delaney L. Metzger, Daniel B. Vann, Philip H. Wong, Jessica M. Subasinghe, Kumudu H. Garlotte, Isabelle K. Phillips, Nicole R. Shetty, Ritu A. Forster, Michael J. Sumien, Nathalie affil: Department of Pharmacology & Neuroscience, UNT HSC, Fort Worth, TX, USA sug: ab: Rationale: Recreational and medical use of stimulants is increasing, and their use may increase susceptibility to aging and promote neurobehavioral impairments. The long-term consequences of these psychostimulants and how they interact with age have not been fully studied. Objectives: Our study investigated whether chronic exposure to the prototypical psychostimulant, methamphetamine (METH), at doses designed to emulate human therapeutic dosing, would confer a pro-oxidizing redox shift promoting long-lasting neurobehavioral impairments. Methods: Groups of 4-month-old male and female C57BL/6 J mice were administered non-contingent intraperitoneal injections of either saline or METH (1.4 mg/kg) twice a day for 4 weeks. Mice were randomly assigned to one experimental group: (i) short-term cognitive assessments (at 5 months), (ii) long-term cognitive assessments (at 9.5 months), and (ii) longitudinal motor assessments (at 5, 7, and 9 months). Brain regions were assessed for oxidative stress and markers of neurotoxicity after behavior testing. Results: Chronic METH exposure induced short-term effects on associative memory, gait speed, dopamine (DA) signaling, astrogliosis in females, and spatial learning and memory, balance, DA signaling, and excitotoxicity in males. There were no long-term effects of chronic METH on cognition; however, it decreased markers of excitotoxicity in the striatum and exacerbated age-associated motor impairments in males. Conclusion: In conclusion, cognitive and motor functions were differentially and sex-dependently affected by METH exposure, and oxidative stress did not seem to play a role in the observed behavioral outcomes. Future studies are necessary to continue exploring the long-term neurobehavioral consequences of drug use in both sexes and the relationship between aging and drugs. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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