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A pure nanoICG-based homogeneous lipiodol formulation: toward precise surgical navigation of primary liver cancer after long-term transcatheter arterial embolization.

Purpose: To surmount the critical issues of indocyanine green (ICG), and thus achieving a precise surgical navigation of primary liver cancer after long-term transcatheter arterial embolization. Methods: In this study, a facile and green pure-nanomedicine formulation technology is developed to const...

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Publicado en:European Journal of Nuclear Medicine & Molecular Imaging Vol. 49; no. 8; pp. 2605 - 2618
Autores principales: Zhang, Yang, Cheng, Hongwei, Chen, Hu, Xu, Peiyao, Ren, En, Jiang, Yonghe, Li, Dengfeng, Gao, Xing, Zheng, Yating, He, Pan, Lin, Huirong, Chen, Biaoqi, Lin, Gan, Chen, Aizheng, Chu, Chengchao, Mao, Jingsong, Liu, Gang
Formato: Journal Article
Publicado: Springer Nature Jul2022
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Jul2022
      vid: 49
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s00259-021-05654-z
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        atl: A pure nanoICG-based homogeneous lipiodol formulation: toward precise surgical navigation of primary liver cancer after long-term transcatheter arterial embolization.
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        au:
          Zhang, Yang
          Cheng, Hongwei
          Chen, Hu
          Xu, Peiyao
          Ren, En
          Jiang, Yonghe
          Li, Dengfeng
          Gao, Xing
          Zheng, Yating
          He, Pan
          Lin, Huirong
          Chen, Biaoqi
          Lin, Gan
          Chen, Aizheng
          Chu, Chengchao
          Mao, Jingsong
          Liu, Gang
        affil: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, 361102, Xiamen, China
      sug:
      ab: Purpose: To surmount the critical issues of indocyanine green (ICG), and thus achieving a precise surgical navigation of primary liver cancer after long-term transcatheter arterial embolization. Methods: In this study, a facile and green pure-nanomedicine formulation technology is developed to construct carrier-free indocyanine green nanoparticles (nanoICG), and which subsequently dispersed into lipiodol via a super-stable homogeneous lipiodol formulation technology (SHIFT nanoICG) for transcatheter arterial embolization combined near-infrared fluorescence-guided precise hepatectomy. Results: SHIFT nanoICG integrates excellent anti-photobleaching capacity, great optical imaging property, and specific tumoral deposition to recognize tumor regions, featuring entire-process enduring fluorescent-guided precise hepatectomy, especially in resection of the indiscoverable satellite lesions (0.6 mm × 0.4 mm) in rabbit bearing VX2 orthotopic hepatocellular carcinoma models. Conclusion: Such a simple and effective strategy provides a promising avenue to address the clinical issue of clinical hepatectomy and has excellent potential for a translational pipeline.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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