Differential effects of citalopram on the intake of high fat or high carbohydrates diets in female and male rats.
Chronic administration of selective serotonin reuptake inhibitors (SSRI), usually prescribed as antidepressants, decreases total energy intake; however, at present the differential effect on the intake of distinct macronutrients and on female vs. male organisms is not clear. On this basis, female an...
| Published in: | Nutritional Neuroscience Vol. 25; no. 7; pp. 1477 - 1488 |
|---|---|
| Main Authors: | , , |
| Format: | Journal Article |
| Published: |
Taylor & Francis Ltd
Jul2022
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=157548973&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 157548973 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1028415X J51 jtl: Nutritional Neuroscience issn: 1028415X maglogo: Y pubinfo: dt: Jul2022 vid: 25 iid: 7 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 157548973 148013968 10.1080/1028415X.2020.1870198 157548973 ppf: 1477 ppct: 11 formats: tig: atl: Differential effects of citalopram on the intake of high fat or high carbohydrates diets in female and male rats. aug: au: De la Fuente-Reynoso, Amparo L. Barrios De Tomasi, Eliana Juárez, Jorge affil: Laboratorio de Farmacología y Conducta, Instituto de Neurociencias, CUCBA, Universidad de Guadalajara, Guadalajara, México sug: ab: Chronic administration of selective serotonin reuptake inhibitors (SSRI), usually prescribed as antidepressants, decreases total energy intake; however, at present the differential effect on the intake of distinct macronutrients and on female vs. male organisms is not clear. On this basis, female and male adult Wistar rats were exposed to two types of diets: (1) a standard balanced diet (BD); or (2) two types of diets simultaneously, (a) one high in carbohydrates (HC); the other (b) high in fat (HF). Both study groups were given a dose of 10 mg/kg/day i.p. of citalopram or a vehicle for 21 days. Food and water consumption and body weight were recorded daily at baseline (BL), during treatment (TX), and post-treatment (PTx1-PTx2). The male rats exposed to BD reduced total energy consumption during treatment with citalopram, but body weight gain decreased both females and males compared to BL. During exposure to the two types of diets, citalopram treatment reduced fat consumption with respect to BL and PTx1 only in the male group. This group also decreased its total energy consumption during TX compared to PTx1. Finally, the females gained less body weight in TX than PTx1, while weight gain in the males during TX decreased with respect to BL and PTx1. Results show a differential effect of citalopram on females vs. males that was dependent on the type of macronutrient administered. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|