Automated measurement of total kidney volume from 3D ultrasound images of patients affected by polycystic kidney disease and comparison to MR measurements.
Purpose: Total kidney volume (TKV) is the most important imaging biomarker for quantifying the severity of autosomal-dominant polycystic kidney disease (ADPKD). 3D ultrasound (US) can accurately measure kidney volume compared to 2D US; however, manual segmentation is tedious and requires expert anno...
| Publicado en: | Abdominal Radiology Vol. 47; no. 7; pp. 2408 - 2420 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jul2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=157613509&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 157613509 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Jul2022 vid: 47 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 157613509 156549209 10.1007/s00261-022-03521-5 157613509 ppf: 2408 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Automated measurement of total kidney volume from 3D ultrasound images of patients affected by polycystic kidney disease and comparison to MR measurements. aug: au: Jagtap, Jaidip M. Gregory, Adriana V. Homes, Heather L. Wright, Darryl E. Edwards, Marie E. Akkus, Zeynettin Erickson, Bradley J. Kline, Timothy L. affil: Department of Radiology, Mayo Clinic, 200 First St. SW, 55905, Rochester, MN, USA sug: ab: Purpose: Total kidney volume (TKV) is the most important imaging biomarker for quantifying the severity of autosomal-dominant polycystic kidney disease (ADPKD). 3D ultrasound (US) can accurately measure kidney volume compared to 2D US; however, manual segmentation is tedious and requires expert annotators. We investigated a deep learning-based approach for automated segmentation of TKV from 3D US in ADPKD patients. Method: We used axially acquired 3D US-kidney images in 22 ADPKD patients where each patient and each kidney were scanned three times, resulting in 132 scans that were manually segmented. We trained a convolutional neural network to segment the whole kidney and measure TKV. All patients were subsequently imaged with MRI for measurement comparison. Results: Our method automatically segmented polycystic kidneys in 3D US images obtaining an average Dice coefficient of 0.80 on the test dataset. The kidney volume measurement compared with linear regression coefficient and bias from human tracing were R2 = 0.81, and − 4.42%, and between AI and reference standard were R2 = 0.93, and − 4.12%, respectively. MRI and US measured kidney volumes had R2 = 0.84 and a bias of 7.47%. Conclusion: This is the first study applying deep learning to 3D US in ADPKD. Our method shows promising performance for auto-segmentation of kidneys using 3D US to measure TKV, close to human tracing and MRI measurement. This imaging and analysis method may be useful in a number of settings, including pediatric imaging, clinical studies, and longitudinal tracking of patient disease progression. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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