Impact of Pancreatic Enzymes on Enteral Fat and Nitrogen Absorption in Short Bowel Syndrome.
Objectives: Patients with short bowel syndrome (SBS) can have a high morbidity rate. To minimize morbidity, enteral autonomy is the primary goal in clinical management of patients with SBS. This is often difficult to achieve because of significant malabsorption. To date, there are limited therapies...
| Publicado en: | Journal of Pediatric Gastroenterology & Nutrition Vol. 75; no. 1; pp. 36 - 42 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Wiley-Blackwell
Jul2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=157663680&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 157663680 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02772116 N1F jtl: Journal of Pediatric Gastroenterology & Nutrition issn: 02772116 maglogo: N pubinfo: dt: Jul2022 vid: 75 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 157663680 157663680 NLM35622082 10.1097/MPG.0000000000003465 NLM35622082 157663680 ppf: 36 ppct: 6 formats: tig: atl: Impact of Pancreatic Enzymes on Enteral Fat and Nitrogen Absorption in Short Bowel Syndrome. aug: au: Sainath, Nina N. Bales, Christina Brownell, Jefferson N. Pickett-Blakely, Octavia Sattar, Aisha Stallings, Virginia A. affil: From the Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia sug: subj: Short Bowel Syndrome Therapy Short Bowel Syndrome Complications Exocrine Pancreatic Insufficiency Etiology Exocrine Pancreatic Insufficiency Drug Therapy Nitrogen Pancreas Adolescence Child Child, Preschool Intestinal Absorption Adult Short Portable Mental Status Questionnaire Impact of Events Scale Scales Adolescent: 13-18 years Child: 6-12 years Child, Preschool: 2-5 years Adult: 19-44 years ab: Objectives: Patients with short bowel syndrome (SBS) can have a high morbidity rate. To minimize morbidity, enteral autonomy is the primary goal in clinical management of patients with SBS. This is often difficult to achieve because of significant malabsorption. To date, there are limited therapies that improve absorption in patients with SBS. The impact of pancreatic enzyme replacement treatment on enteral absorption has not been studied in this population and was the primary aim of this study.Subjects/methods: This was an interventional study in 11 subjects (6 pediatric subjects ages 4.0-17.9 years, 5 adult subjects 18-75 years) that compared enteral absorption in each subject before and after pancreatic enzyme medication (Creon). Coefficient of fat absorption (CFA) and coefficient of nitrogen absorption (CNA) were used as markers of enteral absorption of fat and protein, respectively.Results: There was no statistically significant mean change in CFA and CNA before and after pancreatic enzyme medication therapy. Six subjects demonstrated an increase in CFA and 8 subjects demonstrated an increase in CNA after the use of pancreatic enzyme medication therapy.Conclusions: There was no statistically significant improvement in enteral fat and protein absorption in the cohort as a whole, though several subjects demonstrated an improvement. These results suggest that some patients with SBS may benefit from treatment with pancreatic enzymes. Further studies are needed to better evaluate the effect of pancreatic enzyme therapy on enteral absorption in subjects with SBS and to characterize factors that may predict a positive response. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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