Antioxidant and Anticarcinogenic Potentials of Propolis for Dimethylhydrazine-Induced Colorectal Cancer in Wistar Rats.
Propolis is a natural compound with anticarcinogenic properties. The present study aimed to compare the inhibitory effect of ethanolic extract of propolis (EEP) and vitamin E on dimethylhydrazine-induced colon lesions in rats. In this study, 60 rats were randomly categorized into six 10-member group...
| Publicado en: | BioMed Research International pp. 1 - 13 |
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| Autores principales: | , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
6/23/2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=157685367&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 157685367 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 6/23/2022 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 157685367 157685367 157685367 10.1155/2022/8497562 157685367 ppf: 1 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Antioxidant and Anticarcinogenic Potentials of Propolis for Dimethylhydrazine-Induced Colorectal Cancer in Wistar Rats. aug: au: Salehi, Alireza Hosseini, Seyed Mohammad Kazemi, Sohrab affil: Department of Pathology, Babol Branch, Islamic Azad University, Babol, Iran sug: subj: Propolis Pharmacodynamics Ethanol Pharmacodynamics Antioxidants Pharmacodynamics Antineoplastic Agents Pharmacodynamics Colorectal Neoplasms Drug Therapy Vitamin E Pharmacodynamics Animal Studies Rats Carcinogens Adverse Effects Cell Line, Tumor Drug Effects Random Assignment Comparative Studies Descriptive Statistics C-Reactive Protein Drug Effects Proteins Drug Effects Creatine Kinase Drug Effects Albumins Drug Effects Adenomatous Polyposis Coli Prevention and Control Antigens Drug Effects Antigens, Tumor Drug Effects Platelet-Derived Growth Factor Drug Effects Oxidative Stress Drug Effects Biological Markers Drug Effects Malondialdehyde Drug Effects Superoxide Dismutase Drug Effects Colon Drug Effects Inflammation Prevention and Control Vitamin E Administration and Dosage Propolis Administration and Dosage ab: Propolis is a natural compound with anticarcinogenic properties. The present study aimed to compare the inhibitory effect of ethanolic extract of propolis (EEP) and vitamin E on dimethylhydrazine-induced colon lesions in rats. In this study, 60 rats were randomly categorized into six 10-member groups. After 13 weeks, blood and colon tissue were sampled to examine some factors. The parameters included red (RBC) and white (WBC) blood cell profile, lactate dehydrogenase (LDH), C-reactive protein (CRP), total protein (TP), creatine kinase (CPK), and albumin, as well as the extent of colon histological lesions, protein expression (adenomatous polyposis coli (APC), proliferating cell nuclear antigen (PCNA), carcinoembryonic antigen (CEA), and platelet-derived growth factor (PDGF)), and oxidative stress markers (total antioxidant capacity (TAC), malondialdehyde (MDA), and superoxide dismutase (SOD)) in colon tissue. A significant decrease was observed in congestion, mitotic index, inflammation, and cell destruction in colon tissue in dimethylhydrazine group in comparison with the control group (P < 0.05). The EEP exposed rats exhibited a significant lower oxidative stress than the DMH group (P < 0.05). Furthermore, the extract significantly affected TAC level (P < 0.05). While the expression level of APC rose substantially in the EEP-treated group compared to the DMH group, the level of PCNA, CEA, and PDGF proteins significantly reduced. It seems that the EEP can efficiently prevent DMH-induced colonic lesions. Furthermore, its effectiveness is more than the vitamin E, which is a strong antioxidant. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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