Converging evidence of impaired brain function in systemic lupus erythematosus: changes in perfusion dynamics and intrinsic functional connectivity.
Purpose: Τhe study examined changes in hemodynamics and functional connectivity in patients with systemic lupus erythematosus (SLE) with or without neuropsychiatric manifestations. Methods: Participants were 44 patients with neuropsychiatric SLE (NPSLE), 20 SLE patients without such manifestations (...
| Publicado en: | Neuroradiology Vol. 64; no. 8; pp. 1593 - 1605 |
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| Autores principales: | , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=157889448&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 157889448 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Aug2022 vid: 64 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 157889448 155583114 157889448 157889448 10.1007/s00234-022-02924-x 157889448 ppf: 1593 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Converging evidence of impaired brain function in systemic lupus erythematosus: changes in perfusion dynamics and intrinsic functional connectivity. aug: au: Papadaki, Efrosini Simos, Nicholas J. Kavroulakis, Eleftherios Bertsias, George Antypa, Despina Fanouriakis, Antonis Maris, Thomas Sidiropoulos, Prodromos Boumpas, Dimitrios T affil: Department of Radiology, School of Medicine, University of Crete, University Hospital of Heraklion, 71003, Heraklion, Crete, Greece sug: subj: Brain Physiopathology Lupus Erythematosus, Systemic Functional Connectivity Evaluation Perfusion Neurologic Manifestations Complications Human Hemodynamics Magnetic Resonance Imaging Descriptive Statistics Motor Skills Cognition ab: Purpose: Τhe study examined changes in hemodynamics and functional connectivity in patients with systemic lupus erythematosus (SLE) with or without neuropsychiatric manifestations. Methods: Participants were 44 patients with neuropsychiatric SLE (NPSLE), 20 SLE patients without such manifestations (non-NPSLE), and 35 healthy controls. Resting-state functional MRI (rs-fMRI) was used to obtain whole-brain maps of (a) perfusion dynamics derived through time shift analysis (TSA), (b) regional functional connectivity (intrinsic connectivity contrast (ICC) coefficients), and (c) hemodynamic-connectivity coupling. Group differences were assessed through independent samples t-tests, and correlations of rs-fMRI indices with clinical variables and neuropsychological test scores were, also, computed. Results: Compared to HC, NPSLE patients demonstrated intrinsic hypoconnectivity of anterior Default Mode Network (DMN) and hyperconnectivity of posterior DMN components. These changes were paralleled by elevated hemodynamic lag. In NPSLE, cognitive performance was positively related to higher intrinsic connectivity in these regions, and to higher connectivity-hemodynamic coupling in posterior DMN components. Uncoupling between hemodynamics and connectivity in the posterior DMN was associated with worse task performance. Non-NPSLE patients displayed hyperconnectivity in posterior DMN and sensorimotor regions paralleled by relatively increased hemodynamic lag. Conclusion: Adaptation of regional brain function to hemodynamic changes in NPSLE may involve locally decreased or locally increased intrinsic connectivity (which can be beneficial for cognitive function). This process may also involve elevated coupling of hemodynamics with functional connectivity (beneficial for cognitive performance) or uncoupling, which may be detrimental for the cognitive skills of NPSLE patients. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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