Is age at menopause decreasing? - The consequences of not completing the generational cohort.
Background: Due to contradictory results in current research, whether age at menopause is increasing or decreasing in Western countries remains an open question, yet worth studying as later ages at menopause are likely to be related to an increased risk of breast cancer. Using data from breast cance...
| Publicado en: | BMC Medical Research Methodology Vol. 22; no. 1; pp. 1 - 18 |
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| Autores principales: | , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
BioMed Central
7/11/2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=157911610&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 157911610 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14712288 1CI1 jtl: BMC Medical Research Methodology issn: 14712288 maglogo: N pubinfo: dt: 7/11/2022 vid: 22 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 157911610 157911610 NLM35818026 157911610 10.1186/s12874-022-01658-x NLM35818026 157911610 ppf: 1 ppct: 17 formats: tig: atl: Is age at menopause decreasing? - The consequences of not completing the generational cohort. aug: au: Martins, Rui Sousa, Bruno de Kneib, Thomas Hohberg, Maike Klein, Nadja Duarte, Elisa Rodrigues, Vítor affil: Departamento de Estatística e Investigação Operacional, Faculdade de Ciências, Universidade de Lisboa, Portugal sug: subj: Menopause Breast Neoplasms Epidemiology Risk Assessment Female Prospective Studies Female ab: Background: Due to contradictory results in current research, whether age at menopause is increasing or decreasing in Western countries remains an open question, yet worth studying as later ages at menopause are likely to be related to an increased risk of breast cancer. Using data from breast cancer screening programs to study the temporal trend of age at menopause is difficult since especially younger women in the same generational cohort have often not yet reached menopause. Deleting these younger women in a breast cancer risk analyses may bias the results. The aim of this study is therefore to recover missing menopause ages as a covariate by comparing methods for handling missing data. Additionally, the study makes a contribution to understanding the evolution of age at menopause for several generations born in Portugal between 1920 and 1970.Methods: Data from a breast cancer screening program in Portugal including 278,282 women aged 45-69 and collected between 1990 and 2010 are used to compare two approaches of imputing age at menopause: (i) a multiple imputation methodology based on a truncated distribution but ignoring the mechanism of missingness; (ii) a copula-based multiple imputation method that simultaneously handles the age at menopause and the missing mechanism. The linear predictors considered in both cases have a semiparametric additive structure accommodating linear and non-linear effects defined via splines or Markov random fields smoothers in the case of spatial variables.Results: Both imputation methods unveiled an increasing trend of age at menopause when viewed as a function of the birth year for the youngest generation. This trend is hidden if we model only women with an observed age at menopause.Conclusion: When studying age at menopause, missing ages must be recovered with an adequate procedure for incomplete data. Imputing these missing ages avoids excluding the younger generation cohort of the screening program in breast cancer risk analyses and hence reduces the bias stemming from this exclusion. In addition, imputing the not yet observed ages of menopause for mostly younger women is also crucial when studying the time trend of age at menopause otherwise the analysis will be biased. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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