The Relationship between VEGFC Gene Polymorphisms and Autoimmune Thyroiditis.
Background. Autoimmune thyroid diseases (AITDs), representative autoimmune diseases, mainly consist of Graves' disease (GD) and Hashimoto's thyroiditis (HT). In this passage, we investigated the association between vascular endothelial growth factor C (VEGFC) gene polymorphisms and AITDs. Methods. A...
| Publicado en: | BioMed Research International pp. 1 - 9 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
7/12/2022
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=157928219&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 157928219 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 7/12/2022 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 157928219 157928219 157928219 10.1155/2022/2603519 157928219 ppf: 1 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The Relationship between VEGFC Gene Polymorphisms and Autoimmune Thyroiditis. aug: au: Gao, Chaoqun Zhu, Jie Qin, Qiu Yang, Xiaorong Jiang, Yanfei Zhang, Jinan affil: Graduate School of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China sug: subj: Vascular Endothelial Growth Factors Polymorphism, Genetic Thyroiditis, Autoimmune Risk Factors Human Female Male Graves' Disease Genotype Polymorphism, Single Nucleotide Mutation Disease Susceptibility Female Male ab: Background. Autoimmune thyroid diseases (AITDs), representative autoimmune diseases, mainly consist of Graves' disease (GD) and Hashimoto's thyroiditis (HT). In this passage, we investigated the association between vascular endothelial growth factor C (VEGFC) gene polymorphisms and AITDs. Methods. A total of 1084 patients with AITDs and 794 healthy controls were tested for VEGFC gene genotypes in four single nucleotide polymorphisms (SNPs) by high-throughput sequencing, and the correlation between VEGFC gene polymorphisms and AITDs was statistically analyzed. Results. The genotype distribution of rs3775194 was statistically associated with AITDs compared with the control group. Rs3775194 was associated with AITDs under the overdominant model, both before and after adjusting for confounding factors, while the other three SNPs were not associated with GD and HT. There was a prominent discrepancy between male healthy controls and male AITD patients under overdominant model in rs3775194 and the recessive model in rs11947611. The genotype distribution of rs3775194 was statistically related to male HT. Conclusion. These results reveal the correlation between VEGFC mutation and AITD susceptibility. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|