Upregulation of Nox4 induces a pro-survival Nrf2 response in cancer-associated fibroblasts that promotes tumorigenesis and metastasis, in part via Birc5 induction.

Background: A pro-oxidant enzyme, NADPH oxidase 4 (Nox4) has been reported to be a critical downstream effector of TGFβ-induced myofibroblast transformation during fibrosis. While there are a small number of studies suggesting an oncogenic role of Nox4 derived from activated fibroblasts, direct evid...

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Bibliographic Details

Published in:	Breast Cancer Research Vol. 24; no. 1; pp. 1 - 20
Main Authors:	Mir, Shakeel, Golden, Briana D. Ormsbee, Griess, Brandon J., Vengoji, Raghupathy, Tom, Eric, Kosmacek, Elizabeth A., Oberley-Deegan, Rebecca E., Talmon, Geoffrey A., Band, Vimla, Teoh-Fitzgerald, Melissa LT.
Format:	Journal Article
Published:	BioMed Central 7/14/2022
Online Access:	View this record in EBSCOhost