Incidence of hospital contacts with acute kidney injury after initiation of second-generation antipsychotics in older adults: a Danish population-based cohort study.
Purpose: To investigate the association between acute kidney injury (AKI) and use of second-generation antipsychotics (SGA) in older adults. Methods: In a population-based cohort study using Danish national registries, new users of SGAs (aged ≥ 65) were identified during 2005–2015. Each SGA user was...
| Published in: | European Journal of Clinical Pharmacology Vol. 78; no. 8; pp. 1341 - 1350 |
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| Main Authors: | , , , , , |
| Format: | research tables/charts Journal Article |
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Springer Nature
Aug2022
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=157988223&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 157988223 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00316970 NP9 jtl: European Journal of Clinical Pharmacology issn: 00316970 maglogo: N pubinfo: dt: Aug2022 vid: 78 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 157988223 157988223 157988223 10.1007/s00228-022-03339-6 157988223 ppf: 1341 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Incidence of hospital contacts with acute kidney injury after initiation of second-generation antipsychotics in older adults: a Danish population-based cohort study. aug: au: Sharon, Reeha Lange, Theis Aakjær, Mia Brøgger Kristiansen, Sarah Baltzer Houlind, Morten Andersen, Morten affil: Pharmacovigilance Research Center, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark sug: subj: Kidney Failure, Acute Risk Factors Antipsychotic Agents Therapeutic Use Antipsychotic Agents Adverse Effects Hospitals Kidney Failure, Acute Epidemiology Human Adult Prospective Studies Aged Aged, 80 and Over Matched Case Control Cox Proportional Hazards Model Descriptive Statistics Confidence Intervals Olanzapine Adverse Effects Quetiapine Adverse Effects Risperidone Adverse Effects Sensitivity and Specificity Adult: 19-44 years Aged: 65+ years Aged, 80 & over ab: Purpose: To investigate the association between acute kidney injury (AKI) and use of second-generation antipsychotics (SGA) in older adults. Methods: In a population-based cohort study using Danish national registries, new users of SGAs (aged ≥ 65) were identified during 2005–2015. Each SGA user was matched to 10 population controls on age, sex, and the SGA initiation date. The outcome was incident AKI within 90 days after the index date. Cox regression was used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs), adjusting for potential confounders. Results: In the study, 36,581 new SGA users and 365,810 controls were included. The 90-day incidence rate of AKI was 4.38 and 1.70 per 1000 person-years among SGA users and controls, respectively, corresponding to a crude HR of 2.57 (1.79–3.68). The fully adjusted HR (aHR) was 1.43 (0.89–2.27) for all SGAs. The risk differed among individual drugs with aHRs for olanzapine 3.50 (1.20–10.23), quetiapine 1.62 (0.81–3.26), and risperidone 0.68 (0.28–1.64). In sensitivity analyses, the aHR declined to 1.24 (0.95–1.61) at 1-year follow-up. Conclusions: Olanzapine use was associated with a significantly increased 90-day AKI risk. For quetiapine, the risk was elevated but not significant, and risperidone had no association. CIs were wide and confounder adjustment largely impacted the estimates. Main limitations included residual confounding and incomplete recording of AKI diagnoses. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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