Artichoke Leaf Extract-Mediated Neuroprotection against Effects of Aflatoxin in Male Rats.
Attenuation of adverse effects of aflatoxin (AFB1) in brains of B1 rats by extracts of leaves of artichoke was studied. The active ingredients in extracts of leaves of artichoke, Cynara scolymus L., were determined by HPLC analysis. In the 42-day experiment, rats were exposed to either sterile water...
| Publicado en: | BioMed Research International pp. 1 - 15 |
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| Autores principales: | , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
7/19/2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=158056447&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 158056447 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 7/19/2022 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 158056447 158056447 158056447 10.1155/2022/4421828 158056447 ppf: 1 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Artichoke Leaf Extract-Mediated Neuroprotection against Effects of Aflatoxin in Male Rats. aug: au: Ibrahim, Enas A. Yousef, Mokhtar I. Ghareeb, Doaa A. Augustyniak, Maria Giesy, John P. Aboul-soud, Mourad A. M. El Wakil, Abeer affil: Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, Egypt sug: subj: Artichoke Pharmacodynamics Plant Leaves Pharmacodynamics Plant Extracts Pharmacodynamics Neuroprotective Agents Aflatoxins Adverse Effects Brain Drug Effects Animal Studies Rats Plant Leaves Analysis Chromatography, High Pressure Liquid Water Dimethyl Sulfoxide Administration and Dosage Plant Extracts Administration and Dosage Aflatoxins Administration and Dosage Lipids Blood Blood Glucose Analysis Insulin Analysis Oxidative Stress Evaluation Enzymes Physiology Antioxidants Physiology Brain Pathology Dietary Supplementation ab: Attenuation of adverse effects of aflatoxin (AFB1) in brains of B1 rats by extracts of leaves of artichoke was studied. The active ingredients in extracts of leaves of artichoke, Cynara scolymus L., were determined by HPLC analysis. In the 42-day experiment, rats were exposed to either sterile water, 4% DMSO, 100 mg artichoke leaf extract/kg body mass, 72 μg aflatoxin B1/kg body mass, or AFB1 plus artichoke leaf extract. Neurotoxicity of AFB1 was determined by an increase in profile of lipids, augmentation of plasmatic glucose and concentrations of insulin, oxidative stress, increased activities of cholinergic enzymes, and a decrease in activities of several antioxidant enzymes and pathological changes in brain tissue. Extracts of artichoke leaf significantly reduced adverse effects caused by AFB1, rescuing most of the parameters to values similar to unexposed controls, which demonstrated that adverse, neurotoxic effects caused by aflatoxin B1 could be significantly reduced by simultaneous dietary supplementation with artichoke leaf extract, which itself is not toxic. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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