Bone aluminum measured in miners exposed to McIntyre powder.
A small pilot study was conducted to test whether the technique of in vivo neutron activation analysis could measure bone aluminum levels in 15 miners who had been exposed to McIntyre Powder over 40 years prior. All miners were over 60 years of age, had worked in mines that used McIntyre Powder, and...
| Publicado en: | Journal of Occupational & Environmental Hygiene Vol. 19; no. 6; pp. 335 - 343 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Jun2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=158078865&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 158078865 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15459624 V1L jtl: Journal of Occupational & Environmental Hygiene issn: 15459624 maglogo: Y pubinfo: dt: Jun2022 vid: 19 iid: 6 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 158078865 156432796 158078865 158078865 10.1080/15459624.2022.2063876 158078865 ppf: 335 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Bone aluminum measured in miners exposed to McIntyre powder. aug: au: Bickley, L. M. Martell, J. Cowan, D. Wilken, D. Yan, W. McNeill, F. E. Zarnke, A. Hedges, K. Chettle, D. R. affil: Department of Physics & Astronomy, McMaster University, Hamilton, Ontario, Canada sug: subj: Trace Elements Aluminum Analysis Bone and Bones Analysis Occupational Exposure Aluminum Adverse Effects Powders Analysis Mining Blue Collar Workers Human Pilot Studies Middle Age Confidence Descriptive Statistics Comparative Studies In Vivo Studies Middle Aged: 45-64 years ab: A small pilot study was conducted to test whether the technique of in vivo neutron activation analysis could measure bone aluminum levels in 15 miners who had been exposed to McIntyre Powder over 40 years prior. All miners were over 60 years of age, had worked in mines that used McIntyre Powder, and were sufficiently healthy to travel from northern to southern Ontario for the measurements. Individual aluminum levels were found to be significantly greater than zero with 95% confidence (p < 0.05) in 7 out of the 15 miners. The inverse variance weighted mean of the 15 participants was 21.77 ± 2.27µgAl/gCa. This was significantly higher (p < 0.001) than in a group of 15 non-occupationally exposed subjects of a comparable age from Southern Ontario who had been measured in a previous study. The inverse variance weighted mean bone aluminum content in the non-occupationally exposed group was 3.51 ± 0.85µgAl/gCa. Since the use of McIntyre Powder ceased in 1979, these subjects had not been exposed for more than 40 years. Calculations of potential levels at the cessation of exposure in the 1970s, using a biological half-life of aluminum in bone of 10 to 20 years predicted levels of bone aluminum comparable with studies performed in dialysis patients in the 1970s and 1980s. This pilot study has shown that the neutron activation analysis technique can determine differences in bone aluminum between McIntyre Powder exposed and non-exposed populations even though 40 years have passed since exposure ceased. The technique has potential application as a biomarker of exposure in cross-sectional studies of the health consequences of exposure to McIntyre Powder. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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