Cerebral Blood Flow in the Salience Network of Individuals with Alcohol Use Disorder.
Aims Magnetic resonance imaging (MRI) studies have identified structural and functional differences in salience network nodes of individuals with alcohol use disorders (AUDs) after chronic exposure to alcohol. However, no studies have investigated cerebral blood flow (CBF) in nontreatment-seeking (N...
| Publicado en: | Alcohol & Alcoholism Vol. 57; no. 4; pp. 445 - 452 |
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| Autores principales: | , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Jul2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=158160873&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 158160873 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07350414 FA3 jtl: Alcohol & Alcoholism issn: 07350414 maglogo: N pubinfo: dt: Jul2022 vid: 57 iid: 4 pid: 622 pub: Oxford University Press / USA artinfo: ui: 158160873 158160873 158160873 10.1093/alcalc/agab062 158160873 ppf: 445 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Cerebral Blood Flow in the Salience Network of Individuals with Alcohol Use Disorder. aug: au: Butcher, Tarah J Chumin, Evgeny J West, John D Dzemidzic, Mario Yoder, Karmen K affil: Department of Radiology and Imaging Sciences, Indiana University School of Medicine , 355 W. 16th St., Indianapolis, IN 46202, USA sug: subj: Alcohol-Related Disorders Cerebrovascular Circulation Human ab: Aims Magnetic resonance imaging (MRI) studies have identified structural and functional differences in salience network nodes of individuals with alcohol use disorders (AUDs) after chronic exposure to alcohol. However, no studies have investigated cerebral blood flow (CBF) in nontreatment-seeking (NTS) individuals with AUD. Methods In this work, we sought to quantify putative CBF deficits in NTS individuals relative to social drinking (SD) controls and determine if CBF in the salience network is associated with AUD severity. Fifteen NTS (36.5 ± 11.2 years old, 30.0 ± 22.7 drinks/week) and 22 SD (35.6 ± 11.9 years old, 9.1 ± 5.7 drinks/week) underwent pseudocontinuous arterial spin labeling MRI. Results Compared with social drinkers, NTS individuals had significantly lower CBF in the right and left dorsal anterior insula, and the left ventral anterior and posterior insula. The Alcohol Use Disorder Identification Test (AUDIT) score showed a significant negative relationship with CBF in the bilateral caudal anterior cingulate cortex. In addition, a significant negative correlation was present between number of standard drinks consumed per week and the left frontal opercular CBF. Conclusion These results provide evidence that insular CBF is negatively associated with heavy drinking, and that severity of alcohol use is related to CBF deficits in key nodes of the salience network. Longitudinal data are needed to understand if disruptions of CBF in the insula and the salience network are a predisposition for or a consequence of chronic AUD. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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