Traditional and Modern Diagnostic Approaches in Diagnosing Pediatric Helicobacter pylori Infection.
Helicobacter pylori (H. pylori) is the most common bacterial infection worldwide, is usually acquired during childhood and is related to gastric carcinogenesis during adulthood. Therefore, its early proper diagnosis and subsequent successful eradication represent the cornerstones of gastric cancer p...
| Published in: | Children Vol. 9; no. 7 |
|---|---|
| Main Authors: | , , |
| Format: | review tables/charts Journal Article |
| Published: |
MDPI
Jul2022
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=158212929&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 158212929 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 22279067 LW6K jtl: Children issn: 22279067 maglogo: N pubinfo: dt: Jul2022 vid: 9 iid: 7 pid: 97109 pub: MDPI artinfo: ui: 158212929 158212929 158212929 10.3390/children9070994 158212929 ppct: 16 formats: tig: atl: Traditional and Modern Diagnostic Approaches in Diagnosing Pediatric Helicobacter pylori Infection. aug: au: Mărginean, Cristina Oana Meliț, Lorena Elena Săsăran, Maria Oana affil: Department of Pediatrics I, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, Gheorghe Marinescu Street No. 38, 540136 Targu Mures, Romania sug: subj: Helicobacter Pylori In Infancy and Childhood Bacterial Infections Stomach Neoplasms Prevention and Control Child Invasive Procedures Endoscopy Biopsy Urease Culture Molecular Imaging Health Care Costs Costs and Cost Analysis Urea Serology Breath Tests Methods Feces Analysis Child: 6-12 years ab: Helicobacter pylori (H. pylori) is the most common bacterial infection worldwide, is usually acquired during childhood and is related to gastric carcinogenesis during adulthood. Therefore, its early proper diagnosis and subsequent successful eradication represent the cornerstones of gastric cancer prevention. The aim of this narrative review was to assess traditional and modern diagnostic methods in terms of H. pylori diagnosis. Several invasive and non-invasive methods were described, each with its pros and cons. The invasive diagnostic methods comprise endoscopy with biopsy, rapid urease tests, histopathological exams, cultures and biopsy-based molecular tests. Among these, probably the most available, accurate and cost-effective test remains histology, albeit molecular tests definitely remain the most accurate despite their high costs. The non-invasive tests consist of urea breath tests, serology, stool antigens and non-invasive molecular tests. Urea breath tests and stool antigens are the most useful in clinical practice both for the diagnosis of H. pylori infection and for monitoring the eradication of this infection after therapy. The challenges related to accurate diagnosis lead to a choice that must be based on H. pylori virulence, environmental factors and host peculiarities. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|