Developmental profiles of schizotypy in the general population: A record linkage study of Australian children aged 11–12 years.
Objectives: The detection of young people at high risk for psychotic disorders has been somewhat narrowly focused on overt symptom‐based markers that reflect mild reality distortion (e.g., psychotic‐like experiences), or prodromal syndromes that are proximal to psychosis onset. The concept of schizo...
| Publicado en: | British Journal of Clinical Psychology Vol. 61; no. 3; pp. 836 - 859 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Sep2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=158341490&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 158341490 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01446657 99B jtl: British Journal of Clinical Psychology issn: 01446657 maglogo: Y pubinfo: dt: Sep2022 vid: 61 iid: 3 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 158341490 155454030 158341490 158341490 10.1111/bjc.12363 158341490 ppf: 836 ppct: 23 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Developmental profiles of schizotypy in the general population: A record linkage study of Australian children aged 11–12 years. aug: au: Green, Melissa J. O'Hare, Kirstie Laurens, Kristin R. Tzoumakis, Stacy Dean, Kimberlie Badcock, Johanna C. Harris, Felicity Linscott, Richard J. Carr, Vaughan J. affil: Discipline of Psychiatry and Mental Health, University of New South Wales, Kensington New South Wales,, Australia sug: subj: Schizotypal Personality Disorder Risk Factors Schizophrenia Risk Factors Risk Assessment Methods Medical Record Linkage Australia Human Child Logistic Regression Child Abuse Australia Adverse Childhood Experiences Child: 6-12 years ab: Objectives: The detection of young people at high risk for psychotic disorders has been somewhat narrowly focused on overt symptom‐based markers that reflect mild reality distortion (e.g., psychotic‐like experiences), or prodromal syndromes that are proximal to psychosis onset. The concept of schizotypy represents a broader framework for investigating risk for schizophrenia (and other disorders) in childhood, before the onset of prodromal or overt symptoms. We sought to detect profiles of risk for psychosis (schizotypy) in a general population sample of 22,137 Australian children aged 11–12 years, and to determine early life risk factors associated with these profiles from data available in linked records (registers). Methods: Fifty‐nine self‐reported items were used as indicators of schizotypy across six broad domains; z‐scores for each domain were subjected to latent profile analyses (LPA). A series of multinomial logistic regressions was used to examine the association between resulting profile (class) membership and several childhood and parental risk factors, and the proportion of children with mental disorders among each schizotypy profile was examined. Results: The LPA revealed three person‐centred profiles referred to as True Schizotypy (n = 1,323; 6.0%), Introverted Schizotypy (n = 4,473; 20.2%), and Affective Schizotypy (n = 4,261; 19.2%), as well as a group of children showing no risk (n = 12,080; 54.6%). Prior exposure to perinatal and familial adversities including childhood maltreatment, as well as poor early childhood development and academic functioning, was variously associated with all risk groups. There was a higher proportion of childhood mental disorder diagnoses among children in the True Schizotypy group, relative to other profiles. Conclusion: Subtle differences in the pattern of exposures and antecedents among schizophrenia liability profiles in childhood may reflect distinct pathogenic pathways to psychotic or other mental illness. Practitioner points: Children aged 11–12 years report characteristics of schizotypy which can be classified into three distinct profiles that may represent different pathological processes towards later mental ill‐health.Early life exposure to perinatal and familial adversities including childhood maltreatment, early childhood developmental vulnerability, and poor academic functioning predict membership in all three childhood schizotypy profiles.Latent liability for schizophrenia (and potentially other mental disorders) may be represented by different profiles of functioning observable in childhood. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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