Moderate adiposity levels counteract protein metabolism modifications associated with aging in rats.
Purpose: Physiological parameters such as adiposity and age are likely to influence protein digestion and utilization. The aim of this study was to evaluate the combined effects of age and adiposity on casein protein and amino acid true digestibility and its postprandial utilization in rats. Methods...
| Publicado en: | European Journal of Nutrition Vol. 61; no. 6; pp. 3189 - 3201 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=158430014&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 158430014 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Sep2022 vid: 61 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 158430014 156376778 158430014 158430014 10.1007/s00394-022-02881-4 158430014 ppf: 3189 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Moderate adiposity levels counteract protein metabolism modifications associated with aging in rats. aug: au: Atallah, Nathalie Gaudichon, Claire Boulier, Audrey Baniel, Alain Azzout-Marniche, Dalila Khodorova, Nadezda Chaumontet, Catherine Piedcoq, Julien Chapelais, Martin Calvez, Juliane affil: Université Paris-Saclay, AgroParisTech, INRAE, UMR PNCA, 75005, Paris, France sug: subj: Adipose Tissue Distribution Evaluation Proteins Metabolism Caseins Metabolism Amino Acids Metabolism Aging Animal Studies Rats Obesity Nitrogen Compounds Dietary Proteins Metabolism Deamination Outcome Assessment Descriptive Statistics ab: Purpose: Physiological parameters such as adiposity and age are likely to influence protein digestion and utilization. The aim of this study was to evaluate the combined effects of age and adiposity on casein protein and amino acid true digestibility and its postprandial utilization in rats. Methods: Four groups were included (n = 7/8): 2 months/normal adiposity, 2 months/high adiposity, 11 months/normal adiposity and 11 months/high adiposity. Rats were given a calibrated meal containing 15N-labeled casein (Ingredia, Arras, France) and were euthanized 6 h later. Digestive contents were collected to assess protein and amino acid digestibilities. 15N enrichments were measured in plasma and urine to determine total body deamination. Fractional protein synthesis rate (FSR) was determined in different organs using a flooding dose of 13C valine. Results: Nitrogen and amino acid true digestibility of casein was around 95–96% depending on the group and was increased by 1% in high adiposity rats (P = 0.04). Higher adiposity levels counteracted the increase in total body deamination (P = 0.03) that was associated with older age. Significant effects of age (P = 0.006) and adiposity (P = 0.002) were observed in the muscle FSR, with age decreasing it and adiposity increasing it. Conclusion: This study revealed that a higher level of adiposity resulted in a slight increase in protein and individual amino acid true digestibility values and seemed to compensate for the metabolic postprandial protein alterations observed at older age. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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