Physiologically based pharmacokinetic combined BTK occupancy modeling for optimal dosing regimen prediction of acalabrutinib in patients alone, with different CYP3A4 variants, co-administered with CYP3A4 modulators and with hepatic impairment.

Purpose: To develop a mathematical model combined between physiologically based pharmacokinetic and BTK occupancy (PBPK-BO) to simultaneously predict pharmacokinetic (PK) and pharmacodynamic (PD) changes of acalabrutinib (ACA) and active metabolite ACP-5862 in healthy humans as well as PD in patient...

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Bibliographic Details

Published in:	European Journal of Clinical Pharmacology Vol. 78; no. 9; pp. 1435 - 1447
Main Authors:	Xu, Lifang, Yu, Shuang, Liu, Huining, Yi, Bowen, Wang, Guopeng, Liu, Yang
Format:	equations & formulas research tables/charts Journal Article
Published:	Springer Nature Sep2022
Online Access:	View this record in EBSCOhost