Relative reinforcing effects of dibutylone, ethylone, and N-ethylpentylone: self-administration and behavioral economics analysis in rats.
Rationale: Following the emergence of methylone as one of the most popular synthetic cathinones, this group of novel psychoactive substance with names ending in "-lone," such as dibutylone, ethylone, and N-ethylpentylone, appeared on the recreational drug market. The pharmacological mechanisms of di...
| Publicado en: | Psychopharmacology Vol. 239; no. 9; pp. 2875 - 2885 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Sep2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=158563448&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 158563448 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Sep2022 vid: 239 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 158563448 157487158 10.1007/s00213-022-06173-x 158563448 ppf: 2875 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Relative reinforcing effects of dibutylone, ethylone, and N-ethylpentylone: self-administration and behavioral economics analysis in rats. aug: au: Lai, Miaojun Fu, Dan Xu, Zeming Du, Han Liu, Huifen Wang, Youmei Xu, Peng Zhou, Wenhua affil: Zhejiang Provincial Key Laboratory of Addiction, Ningbo Kangning Hospital, School of Medicine, Ningbo University, Zhejiang Province, 315201, Ningbo, People's Republic of China sug: ab: Rationale: Following the emergence of methylone as one of the most popular synthetic cathinones, this group of novel psychoactive substance with names ending in "-lone," such as dibutylone, ethylone, and N-ethylpentylone, appeared on the recreational drug market. The pharmacological mechanisms of dibutylone, ethylone, and N-ethylpentylone are well understood; however, to date, the reinforcing effects of dibutylone, ethylone, and N-ethylpentylone are still unclear. Objectives: This study aimed to examine the self-administration of dibutylone, ethylone, and N-ethylpentylone relative to methamphetamine (METH) and to quantify their relative reinforcing effectiveness using behavioral economic analysis. Methods: Male Sprague–Dawley rats were trained to self-administer METH (0.05 mg/kg) under a fixed-ratio 1 (FR1) schedule. Following the training, dose substitution was used to generate full dose–response curves for METH and the three synthetic cathinones. According to the first doses on the descending limb of the dose–response curves, rats were trained to self-administer METH (0.05 mg/kg), dibutylone (0.1 mg·kg−1·infusion−1), ethylone (0.4 mg·kg−1·infusion−1), or N-ethylpentylone (0.1 mg·kg−1·infusion−1) under an FR1 schedule, and a behavioral economic evaluation of their reinforcing effectiveness was then performed. Results: Dibutylone, ethylone, and N-ethylpentylone functioned as reinforcers, and the inverted U-shaped dose–response curves were obtained. The rank order of reinforcing potency in this procedure was METH > N-ethylpentylone ≈ dibutylone > ethylone. In the economic analysis, the comparisons of the essential value (EV) transformed from demand elasticity (α) indicated that the rank order of efficacy as reinforcers was METH (EV = 7.93) ≈ dibutylone (EV = 7.81) > N-ethylpentylone (EV = 5.21) ≈ ethylone (EV = 4.19). Conclusions: These findings demonstrated that dibutylone, ethylone, and N-ethylpentylone function as reinforcers and have addictive potential, suggesting that the modification of α-alkyl and N-alkyl side chains may affect their reinforcing efficacy. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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