The Potential of Plant-Derived Extracts and Compounds to Augment Anticancer Effects of Chemotherapeutic Drugs.
Plant extracts comprise a complex mixture of natural compounds with diverse biological activities including anticancer activities. This has made the use of plant extracts a trending strategy in cancer treatment. In addition, plants' active constituents such as polyphenols could confer protective eff...
| Publicado en: | Nutrition & Cancer Vol. 74; no. 9; pp. 3058 - 3077 |
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| Autores principales: | , , , |
| Formato: | review tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=158597505&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 158597505 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2022 vid: 74 iid: 9 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 158597505 157322769 158597505 158597505 10.1080/01635581.2022.2069274 158597505 ppf: 3058 ppct: 19 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The Potential of Plant-Derived Extracts and Compounds to Augment Anticancer Effects of Chemotherapeutic Drugs. aug: au: Ng, Chu Xin Affendi, Muzaira Mazrul Chong, Pei Pei Lee, Sau Har affil: School of Biosciences, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Selangor, Malaysia sug: subj: Plant Extracts Pharmacodynamics Antineoplastic Agents Pharmacodynamics Drug Synergism Neoplasms Drug Therapy Fungi Ginseng Pharmacodynamics Curcumin Pharmacodynamics Flavones Pharmacodynamics In Vivo Studies In Vitro Studies Polyphenols Pharmacodynamics Drug Toxicity Prevention and Control Cells Drug Effects Signal Transduction Drug Effects Neoplasms Physiopathology Antineoplastic Agents Administration and Dosage Antineoplastic Agents Adverse Effects Drug Resistance, Multiple Transferases Drug Effects NF-kappa B Drug Effects Enzymes Drug Effects ab: Plant extracts comprise a complex mixture of natural compounds with diverse biological activities including anticancer activities. This has made the use of plant extracts a trending strategy in cancer treatment. In addition, plants' active constituents such as polyphenols could confer protective effects on normal cells against damage by free radicals as well as lessen the toxicity of chemotherapeutic drugs. Recently, many emerging studies revealed the combinatory uses of plant extracts and individual therapeutic compounds that could be a promising panacea in hampering multiple signaling pathways involved in cancer development and progression. Besides enhancing the therapeutic efficacy, this has also been proven to reduce the dosage of chemotherapeutic drugs used, and hence overcome multiple drug resistance and minimize treatment side effects. Notably, combined use of plant extracts with chemotherapeutics drugs was shown to enhance anticancer effects through modulating various signaling pathways, such as P13K/AKT, NF-κB, JNK, ERK, WNT/β-catenin, and many more. Hence, this review aims to comprehensively summarize both In Vitro and In Vivo mechanisms of actions of well-studied plant extracts, such as Ganoderma Lucidum, Korean red ginseng, Garcinia sp., curcumin, and luteolin extracts in augmenting anticancer properties of the conventional chemotherapeutic drugs from an extensive literature search of recent publications. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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