Using machine learning algorithms to enhance the diagnostic performance of electrical impedance myography.
Introduction/aims: We assessed the classification performance of machine learning (ML) using multifrequency electrical impedance myography (EIM) values to improve upon diagnostic outcomes as compared to those based on a single EIM value.Methods: EIM data was obtained from unilateral excised gastrocn...
| Publicado en: | Muscle & Nerve Vol. 66; no. 3; pp. 354 - 362 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Wiley-Blackwell
Sep2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=158633954&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 158633954 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0148639X 2S7 jtl: Muscle & Nerve issn: 0148639X maglogo: Y pubinfo: dt: Sep2022 vid: 66 iid: 3 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 158633954 157903246 158633954 NLM35727064 10.1002/mus.27664 NLM35727064 158633954 ppf: 354 ppct: 8 formats: tig: atl: Using machine learning algorithms to enhance the diagnostic performance of electrical impedance myography. aug: au: Pandeya, Sarbesh R. Nagy, Janice A. Riveros, Daniela Semple, Carson Taylor, Rebecca S. Hu, Alice Sanchez, Benjamin Rutkove, Seward B. affil: Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston Massachusetts,, USA sug: subj: Myography Amyotrophic Lateral Sclerosis Diagnosis Animals Algorithms Mice Electric Impedance Muscle, Skeletal Clinical Assessment Tools Scales Arthritis Impact Measurement Scales ab: Introduction/aims: We assessed the classification performance of machine learning (ML) using multifrequency electrical impedance myography (EIM) values to improve upon diagnostic outcomes as compared to those based on a single EIM value.Methods: EIM data was obtained from unilateral excised gastrocnemius in eighty diseased mice (26 D2-mdx, Duchenne muscular dystrophy model, 39 SOD1G93A ALS model, and 15 db/db, a model of obesity-induced muscle atrophy) and 33 wild-type (WT) animals. We assessed the classification performance of a ML random forest algorithm incorporating all the data (multifrequency resistance, reactance and phase values) comparing it to the 50 kHz phase value alone.Results: ML outperformed the 50 kHz analysis as based on receiver-operating characteristic curves and measurement of the area under the curve (AUC). For example, comparing all diseases together versus WT from the test set outputs, the AUC was 0.52 for 50 kHz phase, but was 0.94 for the ML model. Similarly, when comparing ALS versus WT, the AUCs were 0.79 for 50 kHz phase and 0.99 for ML.Discussion: Multifrequency EIM using ML improves upon classification compared to that achieved with a single-frequency value. ML approaches should be considered in all future basic and clinical diagnostic applications of EIM. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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