Modified cued recall test in the French population with Down syndrome: A retrospective medical records analysis.
Background: Adults with Down syndrome (DS) are at increased risk of developing Alzheimer's disease (AD) due to genetic predisposition. Identification of patients with AD is difficult since intellectual disabilities (ID) may confound diagnosis. The objective of this study was to evaluate the ability...
| Publicado en: | Journal of Intellectual Disability Research Vol. 66; no. 8; pp. 690 - 704 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Aug2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=158634356&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 158634356 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09642633 EUL jtl: Journal of Intellectual Disability Research issn: 09642633 maglogo: Y pubinfo: dt: Aug2022 vid: 66 iid: 8 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 158634356 157537399 158634356 158634356 10.1111/jir.12957 158634356 ppf: 690 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Modified cued recall test in the French population with Down syndrome: A retrospective medical records analysis. aug: au: Sacco, S. Falquero, S. Bouis, C. Akkaya, M. Gallard, J. Pichot, A. Radice, G. Bazin, F. Montestruc, F. Hiance‐Delahaye, A. Rebillat, A.‐S. affil: Institut Jérôme Lejeune, Paris, France sug: subj: Down Syndrome Complications Alzheimer's Disease Diagnosis Neuropsychological Tests Cues Clinical Assessment Tools Evaluation Instrument Validation Human Retrospective Design Male Female Adult Middle Age Descriptive Statistics Data Analysis Software Record Review Validation Studies Repeated Measures Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Background: Adults with Down syndrome (DS) are at increased risk of developing Alzheimer's disease (AD) due to genetic predisposition. Identification of patients with AD is difficult since intellectual disabilities (ID) may confound diagnosis. The objective of this study was to evaluate the ability of the French version of the modified cued recall test (mCRT) to distinguish between subjects with and without AD in the adult DS population. Methods: This was a retrospective, single‐centre, medical records study including data between March 2014 and July 2020. Adults aged ≥30 years with DS who had at least one mCRT record available were eligible. Age, sex and ID level were extracted, and subjects were attributed to three groups: patients with AD, patients with co‐occurring conditions that may impact cognitive function and subjects without AD. mCRT scores, adjusted by sex, age and ID level, were compared between groups. The optimal cut‐off value to distinguish between patients with and without AD was determined using the receiver operating characteristic curve. The impact of age and ID level on mCRT scores was assessed. Results: Overall, 194 patients with DS were included: 12 patients with AD, 94 patients with co‐occurring conditions and 88 healthy subjects. Total recall scores were significantly lower (P < 0.0001) in patients with AD compared with healthy subjects. The optimal cut‐off value to discriminate between patients with AD and healthy subjects was 22, which compares well with the cut‐off value of 23 originally reported for the English version of the mCRT. Patients aged 30–44 years had higher mCRT total recall scores compared with patients aged ≥45 years (P = 0.0221). Similarly, patients with mild ID had higher mCRT scores compared with patients with severe ID (P < 0.0001). Interpretation: The mCRT is a sensitive tool that may help in the clinical diagnosis of AD in subjects with DS. Early recognition of AD is paramount to deliver appropriate interventions to this vulnerable population. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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