Peripheral Ulcerative Keratitis: A Review.
Peripheral ulcerative keratitis (PUK) is a rare but serious ocular condition that is an important clinical entity due to its ophthalmological and systemic implications. It is characterized by progressive peripheral corneal stromal thinning with an associated epithelial defect and can be associated w...
| Publicado en: | Journal of Ophthalmic & Vision Research Vol. 17; no. 2; pp. 252 - 276 |
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| Autores principales: | , , , , , , , , |
| Formato: | review tables/charts Journal Article |
| Publicado: |
Knowledge E DMCC
Apr-Jun2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=158658897&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 158658897 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20082010 AY5S jtl: Journal of Ophthalmic & Vision Research issn: 20082010 maglogo: N pubinfo: dt: Apr-Jun2022 vid: 17 iid: 2 pid: 35682 pub: Knowledge E DMCC artinfo: ui: 158658897 158658897 158658897 10.18502/jovr.v17i2.10797 158658897 ppf: 252 ppct: 24 formats: fmt: @attributes: type: P tig: atl: Peripheral Ulcerative Keratitis: A Review. aug: au: Hassanpour, Kiana ElSheikh, Reem H. Arabi, Amir Frank, Charles R. Elhusseiny, Abdelrahman M. Eleiwa, Taher K. Arami, Shiva Djalilian, Ali R. Kheirkhah, Ahmad affil: Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran sug: subj: Corneal Ulcer Etiology Corneal Ulcer Pathology Corneal Ulcer Therapy Rare Diseases Autoimmune Diseases Matrix Metalloproteinases ab: Peripheral ulcerative keratitis (PUK) is a rare but serious ocular condition that is an important clinical entity due to its ophthalmological and systemic implications. It is characterized by progressive peripheral corneal stromal thinning with an associated epithelial defect and can be associated with an underlying local or systemic pro-inflammatory condition, or present in an idiopathic form (Mooren ulcer). Associated conditions include autoimmune diseases, systemic and ocular infections, dermatologic diseases, and ocular surgery. Cell-mediated and autoantibody- mediated immune responses have been implicated in the pathogenesis of PUK, destroying peripheral corneal tissue via matrix metalloproteinases. Clinically, patients with PUK present with painful vision loss, a peripheral corneal ulcer, and often adjacent scleritis, episcleritis, iritis, or conjunctivitis. Diagnostic evaluation should be focused on identifying the underlying etiology and ruling out conditions that may mimic PUK, including marginal keratitis and Terrien marginal degeneration. Treatment should be focused on reducing local disease burden with topical lubrication, while simultaneously addressing the underlying cause with antimicrobials or anti-inflammatory when appropriate. Existing and emerging biologic immunomodulatory therapies have proven useful in PUK due to autoimmune conditions. Surgical treatment is generally reserved for cases of severe thinning or corneal perforation. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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