Effective connectivity of the left-ventral occipito-temporal cortex during visual word processing: Direct causal evidence from TMS-EEG co-registration.
As an interface between the visual and language system, the left ventral occipito-temporal cortex (left-vOT) plays a key role in reading. This functional role is supported by anatomical and functional connections between the area and other brain regions within and outside the language network. Never...
| Publicado en: | Cortex: A Journal Devoted to the Study of the Nervous System & Behavior Vol. 154; pp. 167 - 184 |
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| Autores principales: | , , , , |
| Formato: | research Journal Article |
| Publicado: |
Masson SPA
Sep2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=158675390&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 158675390 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00109452 GMP jtl: Cortex: A Journal Devoted to the Study of the Nervous System & Behavior issn: 00109452 maglogo: N pubinfo: dt: Sep2022 vid: 154 pid: 12473 pub: Masson SPA artinfo: ui: 158675390 158675390 NLM35780753 158675390 10.1016/j.cortex.2022.06.004 NLM35780753 158675390 ppf: 167 ppct: 17 formats: tig: atl: Effective connectivity of the left-ventral occipito-temporal cortex during visual word processing: Direct causal evidence from TMS-EEG co-registration. aug: au: Planton, Samuel Wang, Shuai Bolger, Deirdre Bonnard, Mireille Pattamadilok, Chotiga affil: Aix Marseille Univ, CNRS, LPL, Laboratoire Parole et Langage, Aix-en-Provence, France sug: subj: Word Processing Brain Mapping Electroencephalography Reading Temporal Lobe Magnetic Resonance Imaging Visual Perception Clinical Assessment Tools ab: As an interface between the visual and language system, the left ventral occipito-temporal cortex (left-vOT) plays a key role in reading. This functional role is supported by anatomical and functional connections between the area and other brain regions within and outside the language network. Nevertheless, only a few studies have investigated how the functional state of this area, which is dependent upon the nature of the task demand and the stimulus being processed, could influence the activity of the connected brain regions. In the present combined TMS-EEG study, we studied the left-vOT effective connectivity by adopting a direct, causal intervention approach. Using TMS, we probed left-vOT activation in different processing contexts and measured the neural propagation of activity from this area to other brain regions. A comparison of neural propagation measured during low-level visual detection of language versus non-language stimuli showed that processing language stimuli reduced neural propagation from the left-vOT to the right occipital cortex. Additionally, compared to the low-level visual detection of language stimuli, performing semantic judgments on the same stimuli further reduced neural propagation to the posterior part of the corpus callosum, right superior parietal lobule and the right anterior temporal lobe. This reduction of cross-hemispheric neural propagation was accompanied by an increase in the collaboration between areas within the left-hemisphere language network. Together, this first evidence from a direct causal intervention approach suggests that processing language stimuli and performing a high-level language task reduce effective connectivity from the left-vOT to the right hemisphere, and may contribute to the left-hemisphere lateralization typically observed during language processing. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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