Biological Dose Optimization for Particle Arc Therapy Using Helium and Carbon Ions.
Purpose: To present biological dose optimization for particle arc therapy using helium and carbon ions.Methods and Materials: Treatment planning and optimization procedures were developed for spot-scanning hadron arc (SHArc) delivery using the RayStation treatment planning system and FRoG dose engin...
| Publicado en: | International Journal of Radiation Oncology, Biology, Physics Vol. 114; no. 2; pp. 334 - 349 |
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| Autores principales: | , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Pergamon Press - An Imprint of Elsevier Science
Oct2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=158727078&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 158727078 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03603016 1ZQ jtl: International Journal of Radiation Oncology, Biology, Physics issn: 03603016 maglogo: N pubinfo: dt: Oct2022 vid: 114 iid: 2 pid: 2410 pub: Pergamon Press - An Imprint of Elsevier Science artinfo: ui: 158727078 158727078 NLM35490991 158727078 10.1016/j.ijrobp.2022.04.025 NLM35490991 158727078 ppf: 334 ppct: 15 formats: tig: atl: Biological Dose Optimization for Particle Arc Therapy Using Helium and Carbon Ions. aug: au: Mein, Stewart Tessonnier, Thomas Kopp, Benedikt Schömers, Christian Harrabi, Semi Abdollahi, Amir Debus, Jürgen Haberer, Thomas Mairani, Andrea affil: Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD) and German Cancer Research Center (DKFZ), Heidelberg, Germany sug: subj: Proton Therapy Methods Radiotherapy, Conformal Methods Male Carbon Therapeutic Use Radiotherapy, Computer-Assisted Methods Radiation Dosage Helium Therapeutic Use Body Regions Radiation Effects Ions Therapeutic Use Scales OARS Multidimensional Functional Assessment Questionnaire Ferrans and Powers Quality of Life Index Human Male ab: Purpose: To present biological dose optimization for particle arc therapy using helium and carbon ions.Methods and Materials: Treatment planning and optimization procedures were developed for spot-scanning hadron arc (SHArc) delivery using the RayStation treatment planning system and FRoG dose engine. The SHArc optimization algorithm is applicable for charged particle beams and determines angle dependencies for spot and energy selection with three main initiatives: (i) achieve standard clinical optimization goals and constraints for target and organs at risk (OARs), (ii) target dose robustness, and (iii) increase linear energy transfer (LET) in the target volume. Three patient cases previously treated at the Heidelberg Ion-beam Therapy Center (HIT) were selected for evaluation of conventional versus arc delivery for the two clinical particle beams (helium [4He] and carbon [12C] ions): glioblastoma, prostate adenocarcinoma, and skull-base chordoma. Biological dose and dose-averaged LET (LETd) distributions for SHArc were evaluated against conventional planning techniques (volumetric modulated arc therapy [VMAT] and 2-field intensity modulated particle therapy) applying the modified microdosimetric kinetic model with (α/β)x = 2 Gy. Clinical viability and deliverability were assessed via evaluation of plan quality, robustness, and irradiation time.Results: For all investigated patient cases, SHArc treatment optimizations met planning goals and constraints for target coverage and OARs, exhibiting acceptable target coverage and reduced normal tissue volumes, with effective dose >10-GyRBE compared with conventional 2F planning. For carbon ions, LETd was increased in the target volume from ∼40-60 to ∼80-140 keV/µm for SHArc compared with conventional treatments. Favorable LETd distributions were possible with the SHArc approach, with maximum LETd in clinical target volume/gross tumor volume and potential reductions of high-LET regions in normal tissues and OARs. Compared with VMAT, SHArc affords substantial reductions in normal tissue dose (40%-70%).Conclusions: SHArc therapy offers potential treatment benefits such as increased normal tissue sparing from higher doses >10-GyRBE, enhanced target LETd, and potential reduction in high-LET components in OARs. Findings justify further development of robust SHArc treatment planning toward potential clinical translation. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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