Polyphenol Mechanisms against Gastric Cancer and Their Interactions with Gut Microbiota: A Review.
The lack of new drugs and resistance to existing drugs are serious problems in gastric cancer(GC) treatment. The research found polyphenols possess anti-Helicobacter pylori(Hp) and antitumor activities and may be used in the research and development of drugs for cancer prevention and treatment. Howe...
| Publicado en: | Current Oncology Vol. 29; no. 8; pp. 5247 - 5262 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
MDPI
Aug2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=158749415&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 158749415 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11980052 5EKK jtl: Current Oncology issn: 11980052 maglogo: N pubinfo: dt: Aug2022 vid: 29 iid: 8 pid: 97109 pub: MDPI artinfo: ui: 158749415 10.3390/curroncol29080417 158749415 ppf: 5247 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Polyphenol Mechanisms against Gastric Cancer and Their Interactions with Gut Microbiota: A Review. aug: au: Li, Matu Zheng, Ya Zhao, Jinyu Liu, Meimei Shu, Xiaochuang Li, Qiang Wang, Yuping Zhou, Yongning affil: The First Clinical Medical School, Lanzhou University, Lanzhou 730000, China sug: ab: The lack of new drugs and resistance to existing drugs are serious problems in gastric cancer(GC) treatment. The research found polyphenols possess anti-Helicobacter pylori(Hp) and antitumor activities and may be used in the research and development of drugs for cancer prevention and treatment. However, polyphenols are affected by their chemical structures and physical properties, which leads to relatively low bioavailability and bioactivity in vivo. The intestinal flora can improve the absorption, utilization, and biological activity of polyphenols, whereas polyphenol compounds can increase the richness of the intestinal flora, reduce the activity of carcinogenic bacteria, stabilize the proportion of core flora, and maintain homeostasis of the intestinal microenvironment. Our review summarizes the gastrointestinal flora-mediated mechanisms of polyphenol against GC. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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