Type 2 Diabetes mellitus treatment intensification and deintensification in primary care: a retrospective cohort study.
The prevalence of type 2 diabetes is increasing worldwide, presenting a considerable clinical and public health burden. Existing evidence demonstrates that optimisation of diabetes treatment regimens can reduce the risk of morbidity and disability. This retrospective observational cohort study aimed...
| Publicado en: | Journal of Pharmacy Practice & Research Vol. 52; no. 4; pp. 311 - 318 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Aug2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=158809788&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 158809788 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1445937X 6CKV jtl: Journal of Pharmacy Practice & Research issn: 1445937X maglogo: N pubinfo: dt: Aug2022 vid: 52 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 158809788 157063444 158809788 158809788 10.1002/jppr.1812 158809788 ppf: 311 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Type 2 Diabetes mellitus treatment intensification and deintensification in primary care: a retrospective cohort study. aug: au: Wong, Jay An Young, Isabel Sim, Ruth Kua, Kok Pim Lee, Shaun Wen Huey affil: School of Pharmacy, Monash University, Subang Jaya, Malaysia sug: subj: Diabetes Mellitus, Type 2 Drug Therapy Disease Management Methods Primary Health Care Treatment Outcomes Human Retrospective Design Prospective Studies Female Male Middle Age Aged Multivariate Analysis Logistic Regression Preprocedural Fasting Blood Glucose Glycated Hemoglobin Middle Aged: 45-64 years Aged: 65+ years Female Male ab: The prevalence of type 2 diabetes is increasing worldwide, presenting a considerable clinical and public health burden. Existing evidence demonstrates that optimisation of diabetes treatment regimens can reduce the risk of morbidity and disability. This retrospective observational cohort study aimed to identify factors associated with treatment intensification and deintensification in people with type 2 diabetes and evaluate effects of the treatment approaches on clinical outcomes. The cohort included 183 patients enrolled in a primary care Diabetes Medication Therapy Adherence Clinic program in Malaysia between 1 January 2016 and 31 March 2020. Multivariable logistic regression analyses were conducted to determine the clinical or socio‐demographic characteristics associated with treatment intensification or deintensification. A total of 175 patients were included in the final analysis. Eighty‐seven patients (49.7%) had their medicine regimens changed, of which 27.4% (n = 48) of patients had their medicines intensified, 8.6% (n = 15) of patients had their medicines deintensified, and 13.7% (n = 24) of patients had their medicines intensified and deintensified. In multivariable analyses, treatment intensification was associated with higher knowledge of medicine scores. No factors were significantly associated with treatment deintensification. Patients who had their medicines intensified and deintensified had a lower post follow‐up target glycated haemoglobin level, fasting plasma glucose, and random blood glucose values compared to the baseline. The study found variability in the frequency of intensification or deintensification of diabetes medicine regimens and the factors associated with it. Treatment deintensification was relatively uncommon. To prevent overtreatment, further investigations are warranted to understand the impact of treatment deintensification on patients who were already receiving intensive therapy for type 2 diabetes. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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