Tumors of the central nervous system among women treated with fertility drugs: a population-based cohort study.
Purpose: To investigate the association between fertility drugs and tumors of the central nervous system (CNS).Methods: This cohort study was based on The Danish Infertility Cohort and included 148,016 infertile women living in Denmark (1995-2017). The study cohort was linked to national registers t...
| Publicado en: | Cancer Causes & Control Vol. 33; no. 10; pp. 1285 - 1294 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Oct2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=158815479&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 158815479 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09575243 ODX jtl: Cancer Causes & Control issn: 09575243 maglogo: N pubinfo: dt: Oct2022 vid: 33 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 158815479 158203430 158815479 NLM35895242 10.1007/s10552-022-01610-w NLM35895242 158815479 ppf: 1285 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Tumors of the central nervous system among women treated with fertility drugs: a population-based cohort study. aug: au: Frandsen, Clarissa L. B. Jensen, Allan Poulsen, Frantz R. Møller, Maria Lindquist, Sofie Albieri, Vanna Nøhr, Bugge Kjær, Susanne K. affil: Lifestyle, Reproduction and Cancer, Danish Cancer Society Research Center, Copenhagen, Denmark sug: subj: Infertility Drug Therapy Infertility Epidemiology Meningioma Fertility Agents Therapeutic Use Meningeal Neoplasms Female Risk Factors Prospective Studies Denmark Checklists Female ab: Purpose: To investigate the association between fertility drugs and tumors of the central nervous system (CNS).Methods: This cohort study was based on The Danish Infertility Cohort and included 148,016 infertile women living in Denmark (1995-2017). The study cohort was linked to national registers to obtain information on use of specific fertility drugs, cancer diagnoses, covariates, emigration, and vital status. Cox proportional hazard regression models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for all CNS tumors and separately for gliomas, meningiomas and diverse benign tumors of the brain and other parts of the CNS.Results: During a median 11.3 years of follow-up, 328 women were diagnosed with CNS tumors. No marked associations were observed between use of the fertility drugs clomiphene citrate, gonadotropins, gonadotropin-releasing hormone receptor modulators and progesterone and CNS tumors. However, use of human chorionic gonadotropin was associated with a decreased rate of meningiomas (HR 0.49 95% CI 0.28-0.87). No clear associations with CNS tumors were observed according to time since first use or cumulative dose for any of the fertility drugs.Conclusion: No associations between use of most types of fertility drugs and CNS tumors were observed. However, our findings only apply to premenopausal women and additional studies with longer follow-up time are necessary. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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