Modeling the cost‐effectiveness and impact on fatal overdose and initiation of buprenorphine–naloxone treatment at syringe service programs.
Aim: To estimate the number of treatment initiations, averted fatal opioid overdoses and the cost‐effectiveness associated with offering buprenorphine–naloxone (buprenorphine) treatment on‐site within existing syringe service programs (SSPs) in Massachusetts, USA. Design, Setting and Participants: T...
| Publicado en: | Addiction Vol. 117; no. 10; pp. 2635 - 2649 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Oct2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=158880493&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 158880493 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09652140 AIO jtl: Addiction issn: 09652140 maglogo: Y pubinfo: dt: Oct2022 vid: 117 iid: 10 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 158880493 156067070 158880493 158880493 10.1111/add.15883 158880493 ppf: 2635 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Modeling the cost‐effectiveness and impact on fatal overdose and initiation of buprenorphine–naloxone treatment at syringe service programs. aug: au: Adams, Joëlla W. Savinkina, Alexandra Fox, Aaron Behrends, Czarina N. Madushani, Rajapaksha W. M. A. Wang, Jianing Chatterjee, Avik Walley, Alexander Y. Barocas, Joshua A. Linas, Benjamin P. affil: Section of Infectious Diseases, Boston Medical Center (BMC), Boston MA,, USA sug: subj: Cost Benefit Analysis Opiate Overdose Drug Therapy Buprenorphine Therapeutic Use Naloxone Therapeutic Use Health Care Costs Program Evaluation Substance Abuse, Intravenous Human Prospective Studies Models, Theoretical Massachusetts Quality-Adjusted Life Years Persons Who Use Intravenous Drugs Treatment Outcomes Descriptive Statistics Male Female Middle Age Middle Aged: 45-64 years Male Female ab: Aim: To estimate the number of treatment initiations, averted fatal opioid overdoses and the cost‐effectiveness associated with offering buprenorphine–naloxone (buprenorphine) treatment on‐site within existing syringe service programs (SSPs) in Massachusetts, USA. Design, Setting and Participants: This was a cohort‐based mathematical model and cost‐effectiveness analysis. We derived model inputs from state and national surveillance data, clinical trials and observational cohort studies. We compared an intervention scenario where 30% of SSP clients initiated buprenorphine treatment on‐site at least once annually to a status quo scenario where no buprenorphine was available on‐site among community treatment providers in Massachusetts, 2020–30. In individuals with opioid use disorder (OUD) we assumed that 80% of SSP clients had recently injected drugs and that treatment within SSPs would have similar or improved retention compared with standard‐of‐care buprenorphine programs, but higher rates of active opioid use while in treatment. Measurements: Number of treatment initiations (i.e. individuals began treatment on a medication for opioid use disorder or entered medically managed withdrawal), averted fatal opioid overdoses, quality‐adjusted life‐years (QALYs) and life‐time discounted costs from a health sector and a limited societal perspective. Findings The status quo scenario resulted in 23 051 fatal overdoses and 1 511 613 treatment initiations over a 10‐year simulation period. An intervention scenario with on‐site SSP buprenorphine treatment averted 4797 (−20.8%) fatal opioid overdoses and resulted in 129 359 (+8.6%) additional treatment initiations compared with the status quo. The intervention scenario was the dominating scenario: providing OUD treatment through Massachusetts SSPs cost less (−$3612 per person) with patients accumulating more QALYs (0.2 per person) compared with the status quo scenario. Conclusions: Offering buprenorphine treatment on‐site within syringe service programs has the potential to decrease fatal overdoses substantially, improve treatment engagement and save on costs. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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