Effect of Vitamin D Supplementation on Serum Lipid Profiles in Children and Adolescence: A Meta-analysis.
Background: Vitamin D deficiency is an important risk factor for some chronic diseases. Some reports suggested that there is an interrelationship between lipids and cholecalciferol. Objectives: This meta-analysis was conducted to summarize the existing evidence of randomized controlled trials (RCTs)...
| Publicado en: | Journal of Pediatrics Review Vol. 10; no. 1; pp. 1 - 16 |
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| Autores principales: | , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Mazandaran University of Medical Sciences
2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=158951398&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 158951398 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23224398 HC3Y jtl: Journal of Pediatrics Review issn: 23224398 maglogo: N pubinfo: dt: 2022 vid: 10 iid: 1 pid: 45683 pub: Mazandaran University of Medical Sciences artinfo: ui: 158951398 158951398 158951398 10.32598/jpr.10.1.987.1 158951398 ppf: 1 ppct: 15 formats: fmt: @attributes: type: P tig: atl: Effect of Vitamin D Supplementation on Serum Lipid Profiles in Children and Adolescence: A Meta-analysis. aug: au: Amiri, Bita Namakin, Kokab Soltani, Maryam Shetty, Sameep Riahi, Seyed Mohammad affil: Department of Pediatrics, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran sug: subj: Vitamin D Pharmacodynamics Dietary Supplementation Lipids Drug Effects Lipids Drug Effects Lipids Blood Human Meta Analysis PubMed Embase Descriptive Statistics Child Adolescence Data Analysis Software Systematic Review Child: 6-12 years Adolescent: 13-18 years ab: Background: Vitamin D deficiency is an important risk factor for some chronic diseases. Some reports suggested that there is an interrelationship between lipids and cholecalciferol. Objectives: This meta-analysis was conducted to summarize the existing evidence of randomized controlled trials (RCTs) to evaluate the effect of vitamin D supplementation on lipid profiles in children and adolescents. Methods: In this systematic review and meta-analysis, databases, such as Web of Science, PubMed, Scopus, Google Scholar, EMBASE, ScienceDirect, Magiran, and SID were searched for studies up to December 21, 2019. This study was conducted according to PRISMA guidelines. I-square was used to measure the existing heterogeneity through included articles. Considering heterogeneity among articles, random-effect models were applied to pool Standardized Mean Differences (SMD) as overall effect size. Study eligibility criteria included children and adolescents (<18 years) and evaluation of the association between vitamin D and lipid profile. A P<0.05 was considered statistically significant and the analyses were conducted by STATA 14.0. Methods: In this systematic review and meta-analysis, databases, such as Web of Science, PubMed, Scopus, Google Scholar, EMBASE, ScienceDirect, Magiran, and SID were searched for studies up to December 21, 2019. This study was conducted according to PRISMA guidelines. I-square was used to measure the existing heterogeneity through included articles. Considering heterogeneity among articles, random-effect models were applied to pool Standardized Mean Differences (SMD) as overall effect size. Study eligibility criteria included children and adolescents (<18 years) and evaluation of the association between vitamin D and lipid profile. A P<0.05 was considered statistically significant and the analyses were conducted by STATA 14.0. Results: A total of 13 trials (number of participant=173) were included in the current metaanalysis. The SMD was 0.23, the vitamin D supplementation was associated with a significant slight increase in high-density lipoproteins (HDL) levels in children and adolescents (SMD 0.23; 95% CI, 0.02, 0.45, P=0.036; I2=57.7%, Egger's P=0.554). We found no significant association between vitamin D supplementation and LDL-cholesterol (SMD -0.10; 95% CI, -0.29, 0.09, P=0.310; I2=0.0%, Egger's P=0.689), total cholesterol (SMD -0.01; 95% CI, -0.20, 0.18, P=0.926; I2=0.0%, Egger's P=0.005), and triglycerides (SMD -0.10; 95% CI, - 0.22, 0.02, P=0.093; I2=0.0%, Egger's P=0.160) levels. Conclusions: Vitamin D can marginally increase HDL levels, without any significant effect on LDL-C, TG, and TC levels. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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