SAPHO Syndrome Presenting With Atlo-Epistrophic Synovitis and Left Vocal Cord Paresis: A Challenging Diagnosis.

SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) is a rare syndrome mainly characterized by cutaneous and osteoarticular manifestations. The most typical osteoarticular manifestations are localized to the anterior chest wall and include a usually noninfectious osteitis, hyperostosis,...

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Publicado en:Clinical Medicine Insights: Arthritis & Musculoskeletal Disorders pp. 1 - 10
Autores principales: Maranini, Beatrice, Ciancio, Giovanni, Rinaldi, Rosa, Borrelli, Massimo, Pugliatti, Maura, Govoni, Marcello
Formato: case study diagnostic images pictorial Journal Article
Publicado: Sage Publications Inc. 9/7/2022
Acceso en línea:Ver este registro en EBSCOhost
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      dt: 9/7/2022
      pid: 20732
      pub: Sage Publications Inc.
      place: Thousand Oaks, California
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        atl: SAPHO Syndrome Presenting With Atlo-Epistrophic Synovitis and Left Vocal Cord Paresis: A Challenging Diagnosis.
      aug:
        au:
          Maranini, Beatrice
          Ciancio, Giovanni
          Rinaldi, Rosa
          Borrelli, Massimo
          Pugliatti, Maura
          Govoni, Marcello
        affil: Rheumatology Unit, Department of Medical Sciences, University of Ferrara, Ferrara, Italy
      sug:
        subj:
          Acquired Hyperostosis Syndrome Diagnosis
          Acquired Hyperostosis Syndrome Symptoms
          Synovitis Etiology
          Vocal Cord Paralysis Etiology
          Atlanto-Axial Joint Pathology
          Osteolysis Etiology
          Neck Pain Etiology
          Skin Manifestations
      ab: SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) is a rare syndrome mainly characterized by cutaneous and osteoarticular manifestations. The most typical osteoarticular manifestations are localized to the anterior chest wall and include a usually noninfectious osteitis, hyperostosis, and synovitis of the sternoclavicular joints. However, clinical presentation of SAPHO syndrome can be quite heterogeneous. Several clinical and radiological features are shared with other well-defined pathological entities, and clinical signs and symptoms often occur at different timepoints. Mainly due to this complexity and its rarity, there are currently no validated diagnostic criteria for SAPHO syndrome. Inflammation of the soft tissues around the bones and possible nerve compression could contribute to dysphagia, hypophonia, or obstruction of the airways. Neurologic manifestations could therefore be part of this multiorgan involvement. Here, we present a case of SAPHO syndrome with atypical onset symptoms, characterized by left vocal cord paralysis, acute neck pain due to osteolytic atlantoepistrophic lesion, and an unusual cutaneous manifestation, diagnosed as mid-dermal elastolysis. The latest two, to the best of our knowledge, have been here first described in a case of SAPHO syndrome.
      pubtype: Academic Journal
      doctype:
        case study
        diagnostic images
        pictorial
        Journal Article
      ougenre: Article
    language: English
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