Recommendation on an updated standardization of serum magnesium reference ranges.
Purpose: Serum magnesium is the most frequently used laboratory test for evaluating clinical magnesium status. Hypomagnesemia (low magnesium status), which is associated with many chronic diseases, is diagnosed using the serum magnesium reference range. Currently, no international consensus for a ma...
| Publicado en: | European Journal of Nutrition Vol. 61; no. 7; pp. 3697 - 3707 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Oct2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=159000222&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 159000222 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Oct2022 vid: 61 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 159000222 157352044 159000222 159000222 10.1007/s00394-022-02916-w 159000222 ppf: 3697 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Recommendation on an updated standardization of serum magnesium reference ranges. aug: au: Rosanoff, Andrea West, Christina Elin, Ronald J. Micke, Oliver Baniasadi, Shadi Barbagallo, Mario Campbell, Emily Cheng, Fu-Chou Costello, Rebecca B. Gamboa-Gomez, Claudia Guerrero-Romero, Fernando Gletsu-Miller, Nana von Ehrlich, Bodo Iotti, Stefano Kahe, Ka Kim, Dae Jung Kisters, Klaus Kolisek, Martin Kraus, Anton Maier, Jeanette A. affil: CMER Center for Magnesium Education and Research, 13-1255 Malama Street, 96778, Pahoa, HI, USA sug: subj: Magnesium Blood Reference Values Human Serum Analysis Hypomagnesemia Diagnosis Magnesium Deficiency Chronic Disease Diagnosis, Laboratory Hospitals Laboratories ab: Purpose: Serum magnesium is the most frequently used laboratory test for evaluating clinical magnesium status. Hypomagnesemia (low magnesium status), which is associated with many chronic diseases, is diagnosed using the serum magnesium reference range. Currently, no international consensus for a magnesemia normal range exists. Two independent groups designated 0.85 mmol/L (2.07 mg/dL; 1.7 mEq/L) as the low cut-off point defining hypomagnesemia. MaGNet discussions revealed differences in serum magnesium reference ranges used by members' hospitals and laboratories, presenting an urgent need for standardization. Methods: We gathered and compared serum magnesium reference range values from our institutions, hospitals, and colleagues worldwide. Results: Serum magnesium levels designating "hypomagnesemia" differ widely. Of 43 collected values, only 2 met 0.85 mmol/L as the low cut-off point to define hypomagnesemia. The remainder had lower cut-off values, which may underestimate hypomagnesemia diagnosis in hospital, clinical, and research assessments. Current serum magnesium reference ranges stem from "normal" populations, which unknowingly include persons with chronic latent magnesium deficit (CLMD). Serum magnesium levels of patients with CLMD fall within widely used "normal" ranges, but their magnesium status is too low for long-term health. The lower serum magnesium reference (0.85 mmol/L) proposed specifically prevents the inclusion of patients with CLMD. Conclusions: Widely varying serum magnesium reference ranges render our use of this important medical tool imprecise, minimizing impacts of low magnesium status or hypomagnesemia as a marker of disease risk. To appropriately diagnose, increase awareness of, and manage magnesium status, it is critical to standardize lower reference values for serum magnesium at 0.85 mmol/L (2.07 mg/dL; 1.7 mEq/L). pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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