Pyoderma Gangrenosum: An Updated Literature Review on Established and Emerging Pharmacological Treatments.
Pyoderma gangrenosum is a rare inflammatory skin disease classified within the group of neutrophilic dermatoses and clinically characterized by painful, rapidly evolving cutaneous ulcers with undermined, irregular, erythematous-violaceous edges. Pyoderma gangrenosum pathogenesis is complex and invol...
| Publicado en: | American Journal of Clinical Dermatology Vol. 23; no. 5; pp. 615 - 635 |
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| Autores principales: | , , , , , |
| Formato: | review tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=159032392&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 159032392 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11750561 C4Q jtl: American Journal of Clinical Dermatology issn: 11750561 maglogo: N pubinfo: dt: Sep2022 vid: 23 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 159032392 157028067 159032392 159032392 10.1007/s40257-022-00699-8 159032392 ppf: 615 ppct: 20 formats: tig: atl: Pyoderma Gangrenosum: An Updated Literature Review on Established and Emerging Pharmacological Treatments. aug: au: Maronese, Carlo Alberto Pimentel, Matthew A. Li, May M. Genovese, Giovanni Ortega-Loayza, Alex G. Marzano, Angelo Valerio affil: Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace, 9, 20122, Milan, Italy sug: subj: Pyoderma Gangrenosum Therapy Algorithms Pyoderma Gangrenosum Physiopathology Skin Diseases Classification Pyoderma Gangrenosum Symptoms Pyoderma Gangrenosum Immunology Interleukins Analysis Tumor Necrosis Factor Analysis T Lymphocytes Immunology Drug Discovery ab: Pyoderma gangrenosum is a rare inflammatory skin disease classified within the group of neutrophilic dermatoses and clinically characterized by painful, rapidly evolving cutaneous ulcers with undermined, irregular, erythematous-violaceous edges. Pyoderma gangrenosum pathogenesis is complex and involves a profound dysregulation of components of both innate and adaptive immunity in genetically predisposed individuals, with the follicular unit increasingly recognized as the putative initial target. T helper 17/T helper 1-skewed inflammation and exaggerated inflammasome activation lead to a dysregulated neutrophil-dominant milieu with high levels of tumor necrosis factor-α, interleukin (IL)-1β, IL-1α, IL-8, IL-12, IL-15, IL-17, IL-23, and IL-36. Low-evidence studies and a lack of validated diagnostic and response criteria have hindered the discovery and validation of new effective treatments for pyoderma gangrenosum. We review established and emerging treatments for pyoderma gangrenosum. A therapeutic algorithm based on available evidence is also provided. For emerging treatments, we review target molecules and their role in the pathogenesis of pyoderma gangrenosum. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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