Single-subject analysis of regional brain volumetric measures can be strongly influenced by the method for head size adjustment.
Purpose : Total intracranial volume (TIV) is often a nuisance covariate in MRI-based brain volumetry. This study compared two TIV adjustment methods with respect to their impact on z-scores in single subject analyses of regional brain volume estimates. Methods: Brain parenchyma, hippocampus, thalamu...
| Publicado en: | Neuroradiology Vol. 64; no. 10; pp. 2001 - 2010 |
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| Autores principales: | , , , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Springer Nature
Oct2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=159104043&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 159104043 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Oct2022 vid: 64 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 159104043 159104043 159104043 10.1007/s00234-022-02961-6 159104043 ppf: 2001 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Single-subject analysis of regional brain volumetric measures can be strongly influenced by the method for head size adjustment. aug: au: Opfer, Roland Krüger, Julia Spies, Lothar Kitzler, Hagen H. Schippling, Sven Buchert, Ralph affil: Jung Diagnostics GmbH, Hamburg, Germany sug: subj: Brain Anatomy and Histology Sex Factors Brain Radiography Thalamus Pathology Multiple Sclerosis Physiopathology Age Factors Human Female Male Magnetic Resonance Imaging Funding Source Regression ROC Curve Hippocampus Pathology Female Male ab: Purpose : Total intracranial volume (TIV) is often a nuisance covariate in MRI-based brain volumetry. This study compared two TIV adjustment methods with respect to their impact on z-scores in single subject analyses of regional brain volume estimates. Methods: Brain parenchyma, hippocampus, thalamus, and TIV were segmented in a normal database comprising 5059 T1w images. Regional volume estimates were adjusted for TIV using the residual method or the proportion method. Age was taken into account by regression with both methods. TIV- and age-adjusted regional volumes were transformed to z-scores and then compared between the two adjustment methods. Their impact on the detection of thalamus atrophy was tested in 127 patients with multiple sclerosis. Results: The residual method removed the association with TIV in all regions. The proportion method resulted in a switch of the direction without relevant change of the strength of the association. The reduction of physiological between-subject variability was larger with the residual method than with the proportion method. The difference between z-scores obtained with the residual method versus the proportion method was strongly correlated with TIV. It was larger than one z-score point in 5% of the subjects. The area under the ROC curve of the TIV- and age-adjusted thalamus volume for identification of multiple sclerosis patients was larger with the residual method than with the proportion method (0.84 versus 0.79). Conclusion: The residual method should be preferred for TIV and age adjustments of T1w-MRI-based brain volume estimates in single subject analyses. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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