DWI-based MR thermometry: could it discriminate Alzheimer's disease from mild cognitive impairment and healthy subjects?
Purpose: The aim of this study is to compare lateral ventricular cerebrospinal fluid (CSF) temperature of the patients with Alzheimer's disease (AD), mild cognitive impairment (MCI), and healthy subjects (HS) using diffusion-weighted imaging (DWI)-based magnetic resonance (MR) thermometry. Methods:...
| Publicado en: | Neuroradiology Vol. 64; no. 10; pp. 1979 - 1988 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Oct2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=159104046&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 159104046 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Oct2022 vid: 64 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 159104046 156782635 159104046 159104046 10.1007/s00234-022-02969-y 159104046 ppf: 1979 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: DWI-based MR thermometry: could it discriminate Alzheimer's disease from mild cognitive impairment and healthy subjects? aug: au: Asfuroğlu, Berrak Barutcu Topkan, Tuğberk Andaç Kaydu, Nesrin Erdoğan Sakai, Koji Öner, Ali Yusuf Karaman, Yahya Yamada, Kei Tali, E. Turgut affil: Department of Radiology, Faculty of Medicine, School of Medicine, Gazi University, 06500, Besevler, Ankara, Turkey sug: subj: Thermography Methods Cerebral Ventricles Radiography Cerebrospinal Fluid Body Temperature Determination Alzheimer's Disease Diagnosis Cognition Disorders Diagnosis Magnetic Resonance Imaging Methods Human Health Status Comparative Studies Neuropsychological Tests Clinical Assessment Tools Mann-Whitney U Test Post Hoc Analysis Kruskal-Wallis Test Neuroradiography ab: Purpose: The aim of this study is to compare lateral ventricular cerebrospinal fluid (CSF) temperature of the patients with Alzheimer's disease (AD), mild cognitive impairment (MCI), and healthy subjects (HS) using diffusion-weighted imaging (DWI)-based magnetic resonance (MR) thermometry. Methods: Seventy-two patients (37 AD, 19 MCI, 16 HS) who underwent 3-T MR examination from September 2018 to August 2019 were included in this study. Smoking habits, education level, disease duration, and comorbidity status were recorded. Patients were assessed using Mini-Mental State Examination (MMSE) and the Clinical Dementia Rating (CDR) score. Brain temperatures were measured using DWI-based MR thermometry. Group comparisons of brain temperature were performed using the Pearson chi-square, Mann–Whitney, and Kruskal–Wallis tests. Further analysis was performed using the post hoc Bonferroni test. Receiver operating characteristic (ROC) analysis was also used. Results: A CDR score of 0.5, 1, and 2 was 2 (5.4%), 14 (37.8%), and 21 (56.8%) in AD, respectively. The median MMSE score had significant differences among groups and also in pairwise comparisons. The median CSF temperature (°C) values showed statistically significant difference among groups (HS: 38.5 °C, MCI: 38.17 °C, AD: 38.0 °C). The post hoc Mann–Whitney U test indicated a significant difference between AD patients and HS (p = 0.009). There were no significant CSF temperature differences in other pairwise comparisons. Conclusion: Lower CSF temperatures were observed in AD patients than in HS, probably due to decreased brain metabolism in AD. DWI-based MR thermometry as a noninvasive imaging method enabling the measurement of CSF temperatures may contribute to the diagnosis of AD. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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