A Functional Near Infrared Spectroscopy Investigation of the Physiological Underpinnings of Visual Cognitive Workload After Concussion...Pediatric Research in Sports Medicine (PRiSM) 9th Annual Meeting, January 27-29, 2022, Houston, Texas
Background: In concussion, functional near infrared spectroscopy (fNIRS) has been shown to detect differences in cortical oxygenation during neurocognitive testing, with concussed adults manifesting less task-based cortical activation compared to controls. In addition, fNIRS has identified significa...
| Publicado en: | Orthopaedic Journal of Sports Medicine Vol. 10; pp. 1 - 4 |
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| Autores principales: | , , , , , , , |
| Formato: | abstract proceedings research Journal Article |
| Publicado: |
Sage Publications Inc.
2022 Suppl 2
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=159163057&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 159163057 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23259671 FUGT jtl: Orthopaedic Journal of Sports Medicine issn: 23259671 maglogo: Y pubinfo: dt: 2022 Suppl 2 vid: 10 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 159163057 159163057 159163057 10.1177/2325967121S00406 159163057 ppf: 1 ppct: 3 formats: tig: atl: A Functional Near Infrared Spectroscopy Investigation of the Physiological Underpinnings of Visual Cognitive Workload After Concussion...Pediatric Research in Sports Medicine (PRiSM) 9th Annual Meeting, January 27-29, 2022, Houston, Texas aug: au: Master, Christina Storey, Eileen Wang, Lei Grady, Matthew McDonald, Catherine Margulies, Susan Arbogast, Kristy Ayaz, Hasan affil: University of Pennsylvania Perelman School of Medicine, Philadelphia, PA sug: subj: Spectroscopy, Near-Infrared Methods Visual Perception Cognition Workload Brain Concussion Task Performance and Analysis Congresses and Conferences Texas Texas ab: Background: In concussion, functional near infrared spectroscopy (fNIRS) has been shown to detect differences in cortical oxygenation during neurocognitive testing, with concussed adults manifesting less task-based cortical activation compared to controls. In addition, fNIRS has identified significantly reduced interhemispheric coherence in adult concussions relative to controls. In addition, adults with greater post-concussive symptom burden demonstrate lower task-related oxygenation in the frontal and dorsolateral prefrontal cortex (DLPFC) and reduced connectivity compared to controls. Hypothesis: The goal of this study was to use fNIRS to identify any differences in visual task-related cortical activation between concussed adolescents and healthy controls while performing a the King-Devick (KD) test. Methods: We enrolled 112 adolescents, ages 12-18 years, with recent concussion and 165 healthy controls as part of a large observational prospective cohort. Participants were provided standardized instructions to read the KD cards while wearing the fNIRS sensor pad. The relative changes in the difference of oxy-and deoxy-hemoglobin concentrations over each task condition for each optode were calculated via the Modified Beer-Lambert Law using local baselines for each task condition period as its beginning. The averaged oxy-hemoglobin concentration changes for each task period were used for statistical analysis of group (e.g., concussed vs healthy) effect. Results: The concussed adolescents (n=112) and healthy controls (n=165) were demographically comparable with respect to age, sex, and race/ethnicity. The concussed group was more likely to have a history of prior concussion (p = <.0001) and migraine (p =.0001) compared to the healthy control group (Table 1). The concussed adolescents were assessed with fNIRS while performing a visual task a median of 10 days after injury (IQR 4-16). The concussed group had significantly lower oxygenation changes that are the difference between oxygenated and deoxygenated hemoglobin as an indicator of task-evoked response, on left lateral prefrontal area (p<.005, FDR q<.005). As expected, there was also a main effect for task condition (cards) at right lateral prefrontal cortex (p<.001, FDR q<.005). Conclusions: fNIRS is able to distinguish concussed adolescents from healthy controls while performing a visual-cognitive task, the K-D test. Injured adolescents with concussion demonstrated a compensatory pattern of cortical activation, suggesting localized brain dysfunction, recruiting from both hemispheres, distinguishing it from the pattern of cortical activation in healthy controls. fNIRS, as a modality, is not only able to differentiate concussion from healthy controls, but also captures the compensatory mechanisms of cortical activation that underlie visual cognitive function after injury. pubtype: Academic Journal doctype: abstract proceedings research Journal Article ougenre: Unknown language: English refInfo: holdings: @attributes: islocal: N |
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