The Volumetric Changes of the Pineal Gland with Age: An Atlas-based Structural Analysis.
There are numerous reports on the facilitatory role of the pineal gland (PG) in brain function, and the size this structure is suggested to be associated with its proper functionality. Previous works which studied the volume of the PG were mostly based on manual delineation of this region. In a rece...
| Publicado en: | Experimental Aging Research Vol. 48; no. 5; pp. 474 - 505 |
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| Autores principales: | , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Oct-Dec2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=159176982&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 159176982 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0361073X 1HO jtl: Experimental Aging Research issn: 0361073X maglogo: N pubinfo: dt: Oct-Dec2022 vid: 48 iid: 5 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 159176982 155187498 159176982 159176982 10.1080/0361073X.2022.2033593 159176982 ppf: 474 ppct: 31 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The Volumetric Changes of the Pineal Gland with Age: An Atlas-based Structural Analysis. aug: au: Sisakhti, Minoo Shafaghi, Lida Batouli, Seyed Amir Hossein affil: Department of Cognitive Psychology, Institute for Cognitive Sciences Studies, Tehran, Iran sug: subj: Pineal Gland Anatomy and Histology Age Factors Magnetic Resonance Imaging Human Adult Middle Age Aged Descriptive Statistics Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years ab: There are numerous reports on the facilitatory role of the pineal gland (PG) in brain function, and the size this structure is suggested to be associated with its proper functionality. Previous works which studied the volume of the PG were mostly based on manual delineation of this region. In a recent work, we developed an MRI atlas for the PG in the standard space, with one of its applications being in volumetric studies. In this study, using structural MRI data from 295 healthy participants in the age range of 19 to 76 years old, and using robust volumetric methods which included the above-mentioned atlas, we estimated the association of ageing with the changes of the PG volume, along with the volume of 48 other brain structures. We observed a linear decline (r= -0.42) over this age range for the PG volume, which showed similarity to the ageing profile of most of the other brain structures. Also, the PG volume showed significant associations with the scores of 9 cognitive tests. This study is the first work with an automated approach to estimate the PG volume, and could be a help to better understand the functionality of the PG in older ages. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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