Aberrant gray matter volume and functional connectivity in Parkinson's disease with minor hallucination.
Background: Minor hallucination (MH) is the most common psychotic symptom in Parkinson's disease (PD); it can develop into well-structured visual hallucination (VH), suggesting that MH may be a staccato form of well-structured VH. However, it remains unclear whether the pathogenesis is the same. The...
| Published in: | Frontiers in Aging Neuroscience Vol. 14; pp. 1 - 14 |
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| Main Authors: | , , , , , , , , , , , , , , |
| Format: | diagnostic images research tables/charts Journal Article |
| Published: |
Frontiers Media S.A.
9/15/2022
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=159430045&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 159430045 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16634365 BG2U jtl: Frontiers in Aging Neuroscience issn: 16634365 maglogo: N pubinfo: dt: 9/15/2022 vid: 14 pid: 40038 pub: Frontiers Media S.A. artinfo: ui: 159430045 159430045 159430045 10.3389/fnagi.2022.923560 159430045 ppf: 1 ppct: 13 formats: tig: atl: Aberrant gray matter volume and functional connectivity in Parkinson's disease with minor hallucination. aug: au: Min Zhong Chenglin Li Hongquan Lu Donghui Xue Yaxi Wang Yinyin Jiang Sha Zhu Ruxin Gu Xu Jiang Bo Shen Jun Zhu Wenbin Zhang Yang Pan Jun Yan Li Zhang affil: Department of Geriatric Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China sug: subj: Gray Matter Pathology Functional Connectivity Hallucinations Parkinson Disease Symptoms Human China Default Mode Network Middle Age Aged Male Female Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Background: Minor hallucination (MH) is the most common psychotic symptom in Parkinson's disease (PD); it can develop into well-structured visual hallucination (VH), suggesting that MH may be a staccato form of well-structured VH. However, it remains unclear whether the pathogenesis is the same. Therefore, the aim of this study was to investigate the altered gray matter volume (GMV) and functional connectivity (FC) of MH in PD to further understand the complex mechanisms. Materials and methods: We included 67 PD patients who attended the outpatient clinic of Nanjing Medical University Affiliated Brain Hospital and recruited 31 healthy controls (HC). Demographic data and clinical characteristics of all subjects were recorded, and cranial structural magnetic resonance imaging (MRI) and resting-state functional MRI data were acquired. Patients were classified into the PD with MH (PD-MH) group and PD without hallucinations or delusions (PD-NH) group. Voxel-based morphometry was used to analyze the differences in GMV in the structural pattern. Seed-based FC was used to analyze the functional pattern. Gaussian random field correction was used, with voxel level P < 0.001 and cluster level P < 0.05 representing statistically significant differences. Finally, the correlation between FC values and scores on the clinical characteristics assessment scale was analyzed. Results: In the GMV analysis, compared to the PD-NH group, the PD-MH group had reduced GMV in the medial superior frontal gyrus (SFGmed). In the FC analysis, the FC between the SFGmed and the left middle occipital gyrus and right calcarine sulcus decreased in the PD-MH group compared with the PD-NH group, while the FC between SFGmed and the left middle temporal gyrus increased. Correlation analysis revealed that the FC values of the SFGmed and right calcarine sulcus were correlated with the assessment scores for anxiety and sleep symptoms. The FC values of the SFGmed and left middle occipital gyrus were correlated with assessment scores for rapid eye movement disorder. Conclusion: The aberrant structure and function of the default mode network and visual processing areas seems to facilitate the generation of MH in PD, as the alteration was previously found in well-structured VH, suggesting that the two hallucinations have similar pathophysiological mechanisms. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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