Surgical site infections after simultaneous pancreas kidney and pancreas transplantation in the Swiss Transplant Cohort Study.
Background: Among hospital-acquired infections, surgical site infections (SSIs) are frequent. SSI in the early post-transplant course poses a relevant threat to transplant recipients.Aim: To determine incidence, risk factors for SSI and its association with post-transplant outcomes and pancreas tran...
| Publicado en: | Journal of Hospital Infection Vol. 128; pp. 47 - 54 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
W B Saunders
Oct2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=159431619&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 159431619 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01956701 4C3 jtl: Journal of Hospital Infection issn: 01956701 maglogo: N pubinfo: dt: Oct2022 vid: 128 pid: 1351 pub: W B Saunders place: Philadelphia, Pennsylvania artinfo: ui: 159431619 159431619 NLM35840001 159431619 10.1016/j.jhin.2022.07.009 NLM35840001 159431619 ppf: 47 ppct: 7 formats: tig: atl: Surgical site infections after simultaneous pancreas kidney and pancreas transplantation in the Swiss Transplant Cohort Study. aug: au: Schreiber, P.W. Laager, M. Boggian, K. Neofytos, D. van Delden, C. Egli, A. Dickenmann, M. Hirzel, C. Manuel, O. Koller, M. Rossi, S. Schmied, B. Gürke, L. Matter, M. Berney, T. de Rougemont, O. Kuster, S.P. Stampf, S. Mueller, N.J. affil: Division of Infectious Diseases and Hospital Epidemiology and University Zurich, University Hospital Zurich, Zurich, Switzerland sug: subj: Pancreas Transplantation Adverse Effects Kidney Transplantation Adverse Effects Surgical Wound Infection Epidemiology Switzerland Adult Prospective Studies Pancreas Risk Factors Kidney Surgical Wound Infection Etiology Social Support Index Impact of Events Scale Human Adult: 19-44 years ab: Background: Among hospital-acquired infections, surgical site infections (SSIs) are frequent. SSI in the early post-transplant course poses a relevant threat to transplant recipients.Aim: To determine incidence, risk factors for SSI and its association with post-transplant outcomes and pancreas transplant (P-Tx) recipients.Methods: Adult simultaneous kidney-pancreas transplantation (SPK-T) and P-Tx recipients with a follow-up of at least 90 days were identified in the Swiss Transplant Cohort Study (STCS) dataset. Except for the categorization of SSIs according to Centers for Disease Control and Prevention (CDC) criteria, all other data were prospectively collected. Risk factors for SSI were investigated with logistic regression. A Weibull accelerated failure-time model was applied to address the impact of SSI on length of stay, correcting for transplant-related complications and delayed graft function.Findings: Of 130 transplant recipients, 108 SPK-Tx and 22 P-Tx, 18 (14%) individuals developed SSI within the first 90 days after transplantation. Deep incisional (seven, 38.9%) and organ/space infections (eight, 44.4%) predominated. In the majority of SSIs (11, 61.1%; two SSIs with simultaneous identification of fungal pathogens) bacteria were detected with Enterococcus spp. being most frequent. The median duration of hospitalization after transplantation was significantly longer in recipients with SSI (median: 26 days; interquartile range (IQR): 19-44) than in patients without SSI (median: 17 days; IQR: 12-25; P = 0.002). In multivariate analysis, SSI was significantly associated with increased length of stay and prolonged the duration of hospitalization by 36% (95% confidence interval: 4-79).Conclusion: SSI after SPK-Tx and P-Tx occurred at a frequency of 14%. Among pathogens, Enterococcus spp. predominated. SSI was independently associated with a longer hospitalization after transplantation. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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