Reported autism diagnosis is associated with psychotic-like symptoms in the Adolescent Brain Cognitive Development cohort.
Although the schizophrenia (SCZ) rate is increased in autism spectrum disorder (ASD), it is difficult to identify which ASD youth will develop psychosis. We explored the relationship between ASD and emerging psychotic-like experiences (PLS) in a sample of 9127 youth aged 9–11 from the Adolescent Bra...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 31; no. 7; pp. 1 - 11 |
|---|---|
| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jul2022
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=159442108&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 159442108 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Jul2022 vid: 31 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 159442108 148992233 159442108 159442108 10.1007/s00787-021-01738-1 159442108 ppf: 1 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Reported autism diagnosis is associated with psychotic-like symptoms in the Adolescent Brain Cognitive Development cohort. aug: au: Jutla, Amandeep Donohue, Meghan Rose Veenstra-VanderWeele, Jeremy Foss-Feig, Jennifer H. affil: Department of Psychiatry, Columbia University, New York, NY, USA sug: subj: Cognition Autism Spectrum Disorder Diagnosis Early Diagnosis Mental Disorders Diagnosed in Childhood Human Confidence Intervals Descriptive Statistics Questionnaires Regression Chi Square Test T-Tests ab: Although the schizophrenia (SCZ) rate is increased in autism spectrum disorder (ASD), it is difficult to identify which ASD youth will develop psychosis. We explored the relationship between ASD and emerging psychotic-like experiences (PLS) in a sample of 9127 youth aged 9–11 from the Adolescent Brain Cognitive Development (ABCD) cohort. We predicted that parent-reported ASD would be associated with PLS severity, and that ASD youth with PLS (ASD+/PLS+) would differ from ASD youth without PLS (ASD+/PLS−) and youth with PLS but not ASD (ASD−/PLS+) in cognitive function. We fit regression models that included parent-reported ASD, family history of psychosis, lifetime trauma, executive function, processing speed, working memory, age, sex, race, ethnicity, and income-to-needs ratio as predictors of Prodromal Questionnaire-Brief Child (PQ-BC) distress score, a continuous index of PLS severity. We assessed cognitive differences using regression models with ASD/PLS status and relevant covariates as predictors of NIH Toolbox measures. ASD increased raw PQ-BC distress scores by 2.47 points (95% CI 1.33–3.61), an effect at least as large as Black race (1.27 points, 95% CI 0.75–1.78), family history of psychosis (1.05 points, 95% CI 0.56–1.54), and Latinx ethnicity (0.99 points, 95% CI 0.53–1.45. We did not identify differences in cognition for ASD+/PLS+ youth relative to other groups. Our finding of association between ASD and PLS in youth is consistent with previous literature and adds new information in suggesting that ASD may be a strong risk factor for PLS even compared to established SCZ risk factors. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|