Survival Outcomes of Breast-Conserving Therapy versus Mastectomy in Early-Stage Breast Cancer, Including Centrally Located Breast Cancer: A SEER-Based Study.
Purpose. This study aims to analyze the survival outcomes of breast cancer (BC) patients, especially centrally located breast cancer (CLBC) patients undergoing breast-conserving therapy (BCT) or mastectomy. Methods. Surveillance, epidemiology, and end results (SEER) data of patients with T1-T2 invas...
| Publicado en: | Breast Journal Vol. 2022; pp. 1 - 14 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
8/27/2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=159445855&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 159445855 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1075122X ET6 jtl: Breast Journal issn: 1075122X maglogo: Y pubinfo: dt: 8/27/2022 vid: 2022 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 159445855 159445855 159445855 10.1155/2022/5325556 159445855 ppf: 1 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Survival Outcomes of Breast-Conserving Therapy versus Mastectomy in Early-Stage Breast Cancer, Including Centrally Located Breast Cancer: A SEER-Based Study. aug: au: Yu, Tianshui Cheng, Weilun Wang, Ting Chen, Ziang Ding, Yu Feng, Jianyuan Duan, Yunqiang Hu, Anbang Li, Mingcui Zhang, Hanyu Li, Yanling Ma, Fei Guo, Baoliang affil: Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China sug: subj: Breast Neoplasms Surgery Lumpectomy Mastectomy Breast Neoplasms Prognosis Treatment Outcomes Survival Analysis Human Female Disease Surveillance Carcinoma, Ductal, Breast Surgery Carcinoma, Lobular Surgery Record Review Chi Square Test Multiple Logistic Regression Cox Proportional Hazards Model Kaplan-Meier Estimator Multivariate Analysis Incidence Cancer Patients Descriptive Statistics Chemotherapy, Cancer Breast Neoplasms Drug Therapy Adolescence Adult Middle Age Aged Breast Neoplasms Radiotherapy Postoperative Period Risk Assessment Breast Neoplasms Mortality Data Analysis Software Models, Statistical Retrospective Design Prospective Studies Confidence Intervals Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Female ab: Purpose. This study aims to analyze the survival outcomes of breast cancer (BC) patients, especially centrally located breast cancer (CLBC) patients undergoing breast-conserving therapy (BCT) or mastectomy. Methods. Surveillance, epidemiology, and end results (SEER) data of patients with T1-T2 invasive ductal or lobular breast cancer receiving BCT or mastectomy were reviewed. We used X-tile software to convert continuous variables to categorical variables. Chi-square tests were utilized to compare baseline information. The multivariate logistic regression model was performed to evaluate the relationship between predictive variables and treatment choice. Survival outcomes were visualized by Kaplan–Meier curves and cumulative incidence function curves and compared using multivariate analyses, including the Cox proportional hazards model and competing risks model. Propensity score matching was performed to alleviate the effects of baseline differences on survival outcomes. Result. A total of 180,495 patients were enrolled in this study. The breast preservation rates fluctuated around 60% from 2000 to 2015. Clinical features including invasive ductal carcinoma (IDC), lower histologic grade, smaller tumor size, fewer lymph node metastases, positive ER and PR status, and chemotherapy use were independently correlated with BCT in both BC and CLBC cohorts. In all the classic Cox models and competing risks models, BCT was an independent favorable prognostic factor for BC, including CLBC patients in most subgroups. In addition, despite the low breast-conserving rate compared with tumors located in the other areas, CLBC did not impair the prognosis of BCT patients. Conclusion. BCT is optional and preferable for most early-stage BC, including CLBC patients. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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