Preoperative CD52 Level Predicts Graft Survival following Kidney Transplantation.
Several factors have been reported to affect graft survival following kidney transplantation. CD52 molecules may increase T cell proliferation and activation, which may contribute to acute graft rejection and graft survival. In the current study, we studied the possible value of preoperative CD52 le...
| Publicado en: | BioMed Research International pp. 1 - 8 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
9/16/2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=159527770&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 159527770 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 9/16/2022 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 159527770 159527770 159527770 10.1155/2022/8949919 159527770 ppf: 1 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Preoperative CD52 Level Predicts Graft Survival following Kidney Transplantation. aug: au: Ramouz, Ali Nikbakhsh, Rajan Khajeh, Elias Sadeghi, Mahmoud Daniel, Volker Schmitzler, Paul Morath, Christian Zeier, Martin Mehrabi, Arianeb Oweira, Hani affil: Department of General Visceral, and Transplantation Surgery, University of Heidelberg, 69120 Heidelberg, Germany sug: subj: Membrane Glycoproteins Blood Antigens, Surface Blood Preoperative Care Graft Survival Kidney Transplantation Kidney Failure, Chronic Surgery Kidney Failure, Chronic Prognosis Human Prospective Studies Enzyme-Linked Immunosorbent Assay Plasma Analysis Graft Rejection Polyomavirus Infections Risk Factors Cytomegalovirus Infections Risk Factors Kaplan-Meier Estimator Univariate Statistics Cox Proportional Hazards Model Creatinine Blood Descriptive Statistics Adult Middle Age Female Male Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Several factors have been reported to affect graft survival following kidney transplantation. CD52 molecules may increase T cell proliferation and activation, which may contribute to acute graft rejection and graft survival. In the current study, we studied the possible value of preoperative CD52 levels in predicting graft survival following renal transplantation. Ninety-six patients with end-stage renal disease who had kidney transplantation were included in the study from our prospective cohort. Blood samples were taken one day before surgery, and plasma CD52 levels were measured using ELISA (Cloud-Clone Corp., Houston, TX, USA). Acute rejection, acute tubular necrosis, delayed graft function, graft loss, BK infection, cytomegalovirus infection, and graft survival were evaluated. The mean age of recipients was 50.08 ± 12.82 years , and 64.6% were male. The incidence of delayed graft function, acute rejection, graft loss (p < 0.01), BK virus infection, and serum creatinine levels were significantly higher in recipients with high preoperative CD52 levels six months after transplantation (p < 0.05). Kaplan–Meier analysis revealed that three-year graft survival was significantly higher in patients with low preoperative CD52 levels (p < 0.0001). Univariate and multivariate Cox regression analyses showed that serum creatinine levels (hazard ratio HR = 1.7 , p < 0.05), acute rejection (HR = 2.919 , p < 0.05), and preoperative CD52 levels (HR = 3.114 , p < 0.05) were independent prognostic factors for graft survival after kidney transplantation. We showed that high preoperative CD52 levels are associated with higher rates of acute rejection, delayed graft function, and BK virus infection and lower rates of graft survival after kidney transplantation. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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