Cardiopulmonary testing in adult patients with β-thalassemia major in comparison to healthy subjects.
β-Thalassemia patients often have a reduced capacity of exercise and abnormal respiratory function parameters, but the reasons are unclear. In order to identify the causes of the exercise limitation, we performed a cardiopulmonary exercise testing (CPET) in a group of 54 adult β-thalassemia major (T...
| Publicado en: | Annals of Hematology Vol. 101; no. 11; pp. 2445 - 2453 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Nov2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=159548046&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 159548046 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09395555 1WU jtl: Annals of Hematology issn: 09395555 maglogo: N pubinfo: dt: Nov2022 vid: 101 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 159548046 159082223 159548046 NLM36100732 10.1007/s00277-022-04974-w NLM36100732 159548046 ppf: 2445 ppct: 8 formats: tig: atl: Cardiopulmonary testing in adult patients with β-thalassemia major in comparison to healthy subjects. aug: au: Piatti, G. Giuditta, M. Consonni, D. Cassinerio, E. Cappellini, M. D. affil: Department of Pathophysiology and Transplantation, University of Milan and Bronchopneumology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, Milan, Italy sug: subj: beta-Thalassemia Therapy Exercise Tolerance Oxygen Quality of Life Exercise Test Methods Research Subjects Oxygen Consumption Adult Iron Clinical Assessment Tools Ferrans and Powers Quality of Life Index Questionnaires Exercise of Self-Care Agency Scale Adult: 19-44 years ab: β-Thalassemia patients often have a reduced capacity of exercise and abnormal respiratory function parameters, but the reasons are unclear. In order to identify the causes of the exercise limitation, we performed a cardiopulmonary exercise testing (CPET) in a group of 54 adult β-thalassemia major (TM) patients without pulmonary arterial hypertension and in a group of healthy control subjects. All subjects underwent cardiac echocardiography and carried out pulmonary function tests. TM patients also filled an IPAQ questionnaire on usual physical activity (PA).Overall, TM patients have a diminished exercise performance in comparison to control subjects. In fact, peak oxygen uptake (V'O2 peak), expressing maximum exercise capacity, was decreased in 81.5% of the patients; similarly, anaerobic threshold (V'O2@AT) and O2 pulse also resulted lowered. In multivariable regression models adjusted for gender, age, BMI, and mean haemoglobin, V'O2 peak and O2 pulse were positively associated with cardiac iron overload (T2*). No ventilatory limitation to exercise was observed. The most important causes of exercise limitation in these patients were muscular deconditioning and reduced cardiac inotropism due to iron deposition. Only 15/54 (27.8%) TM patients used to perform vigorous physical activity. These results suggest that a program of regular physical activity may be useful to increase the tolerance to effort and therefore to improve the quality of life in these patients. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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