Effects of aging on cognitive and brain inter-network integration patterns underlying usual and dual-task gait performance.
Introduction: Aging affects the interplay between cognition and gait performance. Neuroimaging studies reported associations between gait performance and structural measures; however, functional connectivity (FC) analysis of imaging data can help to identify dynamic neural mechanisms underlying opti...
| Publicado en: | Frontiers in Aging Neuroscience Vol. 14; pp. 1 - 13 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Frontiers Media S.A.
9/28/2022
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=159643289&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 159643289 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16634365 BG2U jtl: Frontiers in Aging Neuroscience issn: 16634365 maglogo: N pubinfo: dt: 9/28/2022 vid: 14 pid: 40038 pub: Frontiers Media S.A. artinfo: ui: 159643289 159643289 159643289 10.3389/fnagi.2022.956744 159643289 ppf: 1 ppct: 12 formats: tig: atl: Effects of aging on cognitive and brain inter-network integration patterns underlying usual and dual-task gait performance. aug: au: Droby, Amgad Varangis, Eleanna Habeck, Christian Hausdorff, Jeffrey M. Stern, Yaakov Mirelman, Anat Maidan, Inbal affil: Laboratory for Early Markers of Neurodegeneration (LEMON), Center for the Study of Movement, Cognition, and Mobility (CMCM), Tel Aviv Sourasky Medical Center, Neurological Institute, Tel Aviv, Israel sug: subj: Aging Cognition Sensory Motor Integration Brain Physiology Task Performance and Analysis Gait Analysis Human Neuroradiography Functional Connectivity Community Living Adult Middle Age Aged Aged, 80 and Over Magnetic Resonance Imaging Neuropsychological Tests Secondary Analysis Male Female Age Factors Demography Psychomotor Performance Funding Source Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Introduction: Aging affects the interplay between cognition and gait performance. Neuroimaging studies reported associations between gait performance and structural measures; however, functional connectivity (FC) analysis of imaging data can help to identify dynamic neural mechanisms underlying optimal performance. Here, we investigated the effects on divergent cognitive and inter-network FC patterns underlying gait performance during usual (UW) and dual-task (DT) walking. Methods: A total of 115 community-dwelling, healthy participants between 20 and 80 years were enrolled. All participants underwent comprehensive cognitive and gait assessments in two conditions and resting state functional MRI (fMRI) scans. Inter-network FC from motor-related to 6 primary cognitive networks were estimated. Step-wise regression models tested the relationships between gait parameters, inter-network FC, neuropsychological scores, and demographic variables. A threshold of p < 0.05 was adopted for all statistical analyses. Results: UW was largely associated with FC levels between motor and sustained attention networks. DT performance was associated with internetwork FC between motor and divided attention, and processing speed in the overall group. In young adults, UW was associated with inter-network FC between motor and sustained attention networks. On the other hand, DT performance was associated with cognitive performance, as well as internetwork connectivity between motor and divided attention networks (VAN and SAL). In contrast, the older age group (> 65 years) showed increased integration between motor, dorsal, and ventral attention, as well as defaultmode networks, which was negatively associated with UW gait performance. Inverse associations between motor and sustained attention inter-network connectivity and DT performance were observed. Conclusion: While UW relies on inter-network FC between motor and sustained attention networks, DT performance relies on additional cognitive capacities, increased motor, and executive control network integration. FC analyses demonstrate that the decline in cognitive performance with aging leads to the reliance on additional neural resources to maintain routine walking tasks. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|