Screening for novel risk factors related to high myopia using machine learning.
Background: High myopia-related complications have become a major cause of irreversible vision loss. Evaluating the association between potential factors and high myopia can provide insights into pathophysiologic mechanisms and further intervention targets for myopia progression.Method: Participants...
| Publicado en: | BMC Ophthalmology Vol. 22; no. 1; pp. 1 - 10 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
BioMed Central
10/13/2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=159661581&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 159661581 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14712415 1CIB jtl: BMC Ophthalmology issn: 14712415 maglogo: N pubinfo: dt: 10/13/2022 vid: 22 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 159661581 159661581 NLM36229775 10.1186/s12886-022-02627-0 NLM36229775 159661581 ppf: 1 ppct: 9 formats: tig: atl: Screening for novel risk factors related to high myopia using machine learning. aug: au: Zhang, Ruiheng Dong, Li Yang, Qiong Zhou, Wenda Wu, Haotian Li, Yifan Li, Heyan Wei, Wenbin affil: Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Beijing Tongren Eye Center, Capital Medical University, Beijing, China sug: subj: Asthma Diagnosis Myopia Epidemiology Asthma Epidemiology Myopia Diagnosis Surveys Prevalence Risk Factors C-Reactive Protein Vitamin A ab: Background: High myopia-related complications have become a major cause of irreversible vision loss. Evaluating the association between potential factors and high myopia can provide insights into pathophysiologic mechanisms and further intervention targets for myopia progression.Method: Participants aged 12-25 years from National Health and Nutrition Examination Survey 2001-2006 were selected for the analysis. Myopia was defined as spherical equivalent (sum of spherical error and half of the cylindrical error) of any eyes ≤-0.5 diopters. High myopia was defined as the spherical equivalent of any eye ≤ - 5.00 diopters. Essential variables were selected by Random Forest algorithm and verified by multivariable logistic regression.Results: A total of 7,033 participants and 74 potential factors, including demographic (4 factors), physical examination (6 factors), nutritional and serological (45 factors), immunological (9 variables), and past medical history factors (10 factors), were included into the analysis. Random Forest algorithm found that several anthropometric, nutritional, and serological factors were associated with high myopia. Combined with multivariable logistic regression, high levels of serum vitamin A was significantly associated with an increased prevalence of high myopia (adjusted odd ratio = 1.46 for 1 µmol/L increment, 95% confidence interval [CI] 1.01-2.10). Furthermore, we found that neither C-reactive protein nor asthma increased the risk and severity of myopia.Conclusion: High levels of serum vitamin A was seemingly associated with an increased prevalence of high myopia. This borderline significant association should be interpreted with caution because the potential increased type I error after the multiple testing. It still needs further investigation regarding the mechanism underlying this association. Neither C-reactive protein nor asthma increased the risk and severity of myopia. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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