Lycium schweinfurthii: new secondary metabolites and their cytotoxic activities.
Two new compounds, 11S-methoxy-11,12-dihydro phytuberin (2) and 9S-methoxy-benzocyclononan-7-one (6), together with twenty-six known ones were isolated from Lycium schweinfurthii (Solanaceae). Their planar structure was established by extensive spectroscopic analyses. The absolute configuration of c...
| Publicado en: | Natural Product Research Vol. 36; no. 20; pp. 5134 - 5142 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Taylor & Francis Ltd
Oct2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=159687705&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 159687705 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14786419 RFT jtl: Natural Product Research issn: 14786419 maglogo: Y pubinfo: dt: Oct2022 vid: 36 iid: 20 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 159687705 151116737 10.1080/14786419.2021.1922902 159687705 ppf: 5134 ppct: 8 formats: tig: atl: Lycium schweinfurthii: new secondary metabolites and their cytotoxic activities. aug: au: Elbermawi, Ahmed Halim, Ahmed F. Mansour, El-Sayed S. Ahmad, Kadria F. Elsbaey, Marwa Ashour, Ahmed Amen, Yhiya El-Gamil, Mohammed M. Tomofumi, Miyamoto Shimizu, Kuniyoshi affil: Department of Pharmacognosy Faculty of Pharmacy, Mansoura University, Mansoura, Egypt sug: ab: Two new compounds, 11S-methoxy-11,12-dihydro phytuberin (2) and 9S-methoxy-benzocyclononan-7-one (6), together with twenty-six known ones were isolated from Lycium schweinfurthii (Solanaceae). Their planar structure was established by extensive spectroscopic analyses. The absolute configuration of compound 6 was determined by time dependent density functional theory calculations (TDDFT). The cytotoxic potential of the isolates was assessed in cultured skin cancer (G-361) and colon cancer (HCT-116 and CaCo-2) cell lines. Certain flavonoids showed the highest cytotoxic activity, with IC50 values ranging from 7.1 to 63.3 µM; meanwhile 5-flurouracil showed IC50 values ranging from 62.4 to >100 µM. All compounds showed minimal toxicity towards normal cells from skin (NHDF-4) and colon (CCD-841), indicating their potential selectivity and safety as cytotoxic candidates. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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